Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures.

Autor: Moyer TJ; Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.; Department of Materials Science and Engineering, Northwestern University, Evanston, IL, 60208, USA., Kassam HA; Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.; Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Bahnson ES; Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.; Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Morgan CE; Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.; Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Tantakitti F; Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.; Department of Materials Science and Engineering, Northwestern University, Evanston, IL, 60208, USA., Chew TL; Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Kibbe MR; Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.; Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA., Stupp SI; Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL, 60611, USA.; Department of Materials Science and Engineering, Northwestern University, Evanston, IL, 60208, USA.; Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.; Department of Chemistry, Northwestern University, Evanston, IL, 60208, USA.
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2015 Jun; Vol. 11 (23), pp. 2750-5. Date of Electronic Publication: 2015 Feb 03.
DOI: 10.1002/smll.201403429
Abstrakt: Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self-assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical nanostructures with an equivalent diameter display no binding.
(© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
Externí odkaz: