'Someday it will be the norm': physician perspectives on the utility of genome sequencing for patient care in the MedSeq Project.

Autor:	Vassy JL; Section of General Internal Medicine, VA Boston Healthcare System, Boston, MA 02130, USA ; Division of General Medicine & Primary Care, Department of Medicine, Brigham & Women's Hospital, Boston, MA 02115, USA ; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA., Christensen KD; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA ; Division of Genetics, Brigham & Women's Hospital, Boston, MA 02115, USA., Slashinski MJ; School of Public Health & Health Sciences, University of Massachusetts, Amherst, MA 01003, USA., Lautenbach DM; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA ; Division of Genetics, Brigham & Women's Hospital, Boston, MA 02115, USA., Raghavan S; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA ; General Medicine Division, Massachusetts General Hospital, Boston, MA 02114, USA., Robinson JO; Center for Medical Ethics & Health Policy, Baylor College of Medicine, Houston, TX 77030, USA., Blumenthal-Barby J; Center for Medical Ethics & Health Policy, Baylor College of Medicine, Houston, TX 77030, USA., Feuerman LZ; Center for Medical Ethics & Health Policy, Baylor College of Medicine, Houston, TX 77030, USA., Lehmann LS; Division of General Medicine & Primary Care, Department of Medicine, Brigham & Women's Hospital, Boston, MA 02115, USA ; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA ; General Medicine Division, Massachusetts General Hospital, Boston, MA 02114, USA., Murray MF; Geisinger Health System, Danville, PA 17822 4910, USA., Green RC; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA ; Division of Genetics, Brigham & Women's Hospital, Boston, MA 02115, USA., McGuire AL; Center for Medical Ethics & Health Policy, Baylor College of Medicine, Houston, TX 77030, USA.
Jazyk:	angličtina
Zdroj:	Personalized medicine [Per Med] 2015; Vol. 12 (1), pp. 23-32.
DOI:	10.2217/pme.14.68
Abstrakt:	Aim: To describe practicing physicians' perceived clinical utility of genome sequencing. Materials & Methods: We conducted a mixed-methods analysis of data from 18 primary care physicians and cardiologists in a study of the clinical integration of whole-genome sequencing. Physicians underwent brief genomics continuing medical education before completing surveys and semi-structured interviews. Results: Physicians described sequencing as currently lacking clinical utility because of its uncertain interpretation and limited impact on clinical decision-making, but they expressed the idea that its clinical integration was inevitable. Potential clinical uses for sequencing included complementing other clinical information, risk stratification, motivating patient behavior change and pharmacogenetics. Conclusion: Physicians given genomics continuing medical education use the language of both evidence-based and personalized medicine in describing the utility of genome-wide testing in patient care.
Databáze:	MEDLINE
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