Intratumoral lymphatic vessel density as a predictor of progression-free and overall survival in locally advanced laryngeal/hypopharyngeal cancer.

Autor: Hurst NJ Jr; Department of Radiation Oncology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan., Dominello M; Department of Radiation Oncology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan., Dyson G; Department of Oncology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan., Jaratli H; Department of Pathology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan., Sharma M; Department of Pathology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan., Ahmed YK; Department of Pathology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan., Melkane AE; Department of Otolaryngology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan., Rose C; Department of Otolaryngology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan., Jacobs J; Department of Otolaryngology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan., Giorgadze T; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York., Kim H; Department of Radiation Oncology, Wayne State University, Detroit Medical Center, Karmanos Cancer Center, Detroit, Michigan.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2016 Apr; Vol. 38 Suppl 1, pp. E417-20. Date of Electronic Publication: 2015 Jun 29.
DOI: 10.1002/hed.24011
Abstrakt: Background: Lymphatic vessel density (LVD) has been shown to be an important predictor of survival in head and neck cancers. We report the predictive value of LVD for progression-free survival (PFS) and overall survival (OS) in laryngeal/hypopharyngeal cancer.
Methods: Fifty-five untreated patients with T3/T4 laryngeal and T4 hypopharyngeal cancer underwent laryngectomy between 1999 and 2010. Surgical specimens were immunostained with D2-40, a specific lymphatic marker. LVDs were determined in tumor vessel "hot spots." Recursive partitioning analysis identified LVD thresholds for both peritumoral (LVDpt) and intratumoral (LVDit) vessels for association with PFS and OS.
Results: Patients with mean LVDit of <11 vessels/mm(2) had 2-year PFS and OS rates of 58% and 65%, respectively, compared to 13% and 13% for those with LVDit ≥11 vessels/mm(2) (p = .06 and .04, respectively).
Conclusion: Intratumoral lymphatic vessel density is predictive of PFS and OS in locally advanced laryngeal/hypopharyngeal cancer. © 2015 Wiley Periodicals, Inc. Head Neck 38: E417-E420, 2016.
(© 2015 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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