A new look at osteomyelitis development--focus on CCR5delta32. Study in patients from Northeast Brazil.

Autor: de Souza Mdo S; Universidade Federal do Ceará, Fortaleza, Ceará, Brazil; Instituto Dr. José Frota, Fortaleza, Ceará, Brazil., de Souza CA; Instituto Dr. José Frota, Fortaleza, Ceará, Brazil., Cunha LM; Universidade Federal do Ceará, Fortaleza, Ceará, Brazil., de Souza AQ; Universidade Federal do Ceará, Fortaleza, Ceará, Brazil., de Morais MS; Universidade Federal do Ceará, Fortaleza, Ceará, Brazil., Rabenhorst SH; Universidade Federal do Ceará, Fortaleza, Ceará, Brazil. Electronic address: srabenhorst@hotmail.com.
Jazyk: angličtina
Zdroj: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2015 Apr; Vol. 31, pp. 61-3. Date of Electronic Publication: 2015 Jan 28.
DOI: 10.1016/j.meegid.2015.01.012
Abstrakt: Introduction: CCR5 receptor exerts an important role in the host immune response. Osteomyelitis is an inflammatory process and Staphylococcus aureus is the principal causative agent of this bone injury complication. A deletion of 32bp (CCR5Δ32) in the CCR5 gene seems to protect against HIV-1, S.aureus and other infections. However, the CCR5Δ32 allele has been associated with an increased risk for other diseases.
Objective: To investigate the function of CCR5 and to gather data about the relationship of the CCR5Δ32 mutation and the risk of developing osteomyelitis as a complication in patients with bone traumas.
Methods: In a study of 153 patients with bone traumas the presence of the CCRΔ32 mutation was determined by PCR.
Results: In this study, the CCR5Δ32 allele was present only in the heterozygous form. Osteomyelitis was more frequent in the wild type carriers (94.87%; 37/39) and most of the CCR5Δ32 carriers (87.5%; 14/16) did not present with osteomyelitis.
Conclusion: The CCR5Δ32 could be associated with protection against osteomyelitis caused by S. aureus, corroborating the data from Alonzo & Torres study, in which CCR5 receptor is required for S. aureus leukotoxin ED (LukED) cytotoxicity.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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