| Autor: |
de Almeida PA, Alves MC, Polonini HC, Calixto SL, Braga Gomes TB, Barros Lataliza AA, da Silveira Ramos CD, Barbosa Raposo NR, de Oliveira Ferreira A, Fernandes Brandão A; Universidade Federal de Juiz de Fora, Rua Jose Lourenco Kelmer, s/n, Campus Universitario, 36036-900 Juiz de Fora, MG, Brazil. marcosbrand2012@gmail.com. |
| Jazyk: |
angličtina |
| Zdroj: |
Current drug delivery [Curr Drug Deliv] 2015; Vol. 12 (2), pp. 157-65. |
| DOI: |
10.2174/1567201812666150130161736 |
| Abstrakt: |
Resveratrol is a phenolic compound that has been widely studied in the last years because of its extensive pharmacological properties. It also has physicochemical properties that are adequate for diffusion through the human skin. An analytical method by high performance liquid chromatography was developed and validated for its determination in transdermal emulsion, as well in receptor media and skin layers. The trans-resveratrol release kinetic followed the Higushi's model (R(2) = 0.9926) with steady-state diffusion flux and lag time of 138.5 µg cm(-2) h(-1) and 0.49 h, respectively. It showed a percentage at 64.96 % for permeation. Thus, the results suggest that the emulsion studied is a potential vehicle for transresveratrol administration by transdermal route. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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