The Effect of Chronic Anabolic-Androgenic Steroid Use on Tp-E Interval, Tp-E/Qt Ratio, and Tp-E/Qtc Ratio in Male Bodybuilders.

Autor:	Alizade E; Department of Cardiology, Kartal Kosuyolu High Specialty Education and Research Hospital, Turkey., Avcı A; Department of Cardiology, Kartal Kosuyolu High Specialty Education and Research Hospital, Turkey., Fidan S; Department of Cardiology, Kartal Kosuyolu High Specialty Education and Research Hospital, Turkey., Tabakçı M; Department of Cardiology, Kartal Kosuyolu High Specialty Education and Research Hospital, Turkey., Bulut M; Department of Cardiology, Kartal Kosuyolu High Specialty Education and Research Hospital, Turkey., Zehir R; Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey., Simsek Z; Department of Cardiology, Kartal Kosuyolu High Specialty Education and Research Hospital, Turkey., Evlice M; Department of Cardiology, Kartal Kosuyolu High Specialty Education and Research Hospital, Turkey., Arslantaş U; Department of Cardiology, Kartal Kosuyolu High Specialty Education and Research Hospital, Turkey., Çakır H; Department of Cardiology, Kartal Kosuyolu High Specialty Education and Research Hospital, Turkey., Emiroglu MY; Department of Cardiology, Kartal Kosuyolu High Specialty Education and Research Hospital, Turkey., Akçakoyun M; Department of Cardiology, Kartal Kosuyolu High Specialty Education and Research Hospital, Turkey.
Jazyk:	angličtina
Zdroj:	Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc [Ann Noninvasive Electrocardiol] 2015 Nov; Vol. 20 (6), pp. 592-600. Date of Electronic Publication: 2015 Jan 28.
DOI:	10.1111/anec.12256
Abstrakt:	Background: The chronic consumption of androgenic anabolic steroids has shown to cause atrial arrhythmias. Several studies have suggested that the interval from the peak to the end of the electrocardiographic T wave (Tp-e) may correspond to the transmural dispersion of repolarization and that increased Tp-e interval and Tp-e/QT ratio are associated with malignant ventricular arrhythmias. The aim of this study was to evaluate repolarization dispersion measured from the 12-lead surface electrocardiogram (including Tp-e interval, Tp-e/QT ratio, and Tp-e/cQT ratio) in bodybuilders who are using anabolic androgenic steroids (AAS). Methods: We selected a population of 33 competitive bodybuilders, including 15 actively using AAS for ≥ 2 years (users) and 18 who had never used AAS (nonusers), all men. Results: QT, cQT, QTd, cQTd, JT, and cJT were significantly increased in AAS users bodybulders compared to the nonusers (all P < 0.001). Tp-e interval, Tp-e/QT ratio, and Tp-e/cQT ratio were also significantly higher in AAS user group compared to the nonuser group (all P < 0.001). QRS duration was not different between the groups. There were negative correlation between E(m) and Tp-e, Tp-e/QT ratio, Tp-e/cQT ration (r = -0.657, P < 0.01; r = -0.607, P = 0.02; r = -0.583, P = 0.02; respectively).There were also negative correlation between S(m) and Tp-e, Tp-e/QT ratio, Tp-e/cQT ration (r = -0.681, P < 0.01; r = -0.549, P = 0.03; r = -0.544, P = 0.023; respectively). Conclusion: In conclusion, we have presented a strong evidence suggesting that Tp-e interval, Tp-e/QT ratio, and Tp-e/QTc ratio were increased in AAS users, which suggest that there might be a link between AAS use and ventricular arrthymias and sudden death. (© 2015 Wiley Periodicals, Inc.)
Databáze:	MEDLINE
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