Oxidative stress and plasma lipoproteins in cancer patients.
| Autor: | Maia FM; Universidade Estadual do Ceará, Fortaleza, CE, Brazil., Santos EB; Universidade Estadual do Ceará, Fortaleza, CE, Brazil., Reis GE; Universidade Estadual do Ceará, Fortaleza, CE, Brazil. |
|---|---|
| Jazyk: | English; Portuguese |
| Zdroj: | Einstein (Sao Paulo, Brazil) [Einstein (Sao Paulo)] 2014 Oct-Dec; Vol. 12 (4), pp. 480-4. Date of Electronic Publication: 2014 Dec 16. |
| DOI: | 10.1590/S1679-45082014RC3110 |
| Abstrakt: | Objective: To evaluate the relation between oxidative stress and lipid profile in patients with different types of cancer. Methods: This was an observational cross-sectional. A total of 58 subjects were evaluated, 33 males, divided into two groups of 29 patients each: Group 1, patients with cancer of the digestive tract and accessory organs; Group 2 patients with other types of cancers, all admitted to a public hospital. The plasma levels (lipoproteins and total cholesterol, HDL, and triglycerides, for example) were analyzed by enzymatic kits, and oxidative stress based on thiobarbituric acid-reactive substances, by assessing the formation of malondialdehyde. Results: In general the levels of malondialdehyde of patients were high (5.00μM) as compared to 3.31μM for healthy individuals. The median values of lipids exhibited normal triacylglycerol (138.78±89.88mg/dL), desirable total cholesterol values (163.04±172.38mg/dL), borderline high LDL (151.30±178.25mg/dL) and low HDL (31.70±22.74mg/dL). Median HDL levels in Group 1 were lower (31.32mg/dL) than the cancer patients in Group 2 (43.67mg/dL) (p=0.038). Group 1 also showed higher levels of oxidative stress (p=0.027). Conclusion: The lipid profile of patients with cancer was not favorable, which seems to have contributed to higher lipid peroxidation rate, generating a significant oxidative stress. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|