Mucociliary clearance, airway inflammation and nasal symptoms in urban motorcyclists.

Autor:	Brant TC; Department of Pathology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil., Yoshida CT; Department of Physiotherapy, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil., Carvalho Tde S; Department of Physiotherapy, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil., Nicola ML; Department of Physiotherapy, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil., Martins JA; Physical Therapy Department, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Braga LM; Department of Physiotherapy, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil., Oliveira RC; Department of Pathology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil., Leyton V; Department of Legal Medicine, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil., André CS; Institute of Mathematics and Statistics, University of São Paulo, São Paulo, SP, Brazil., Saldiva PH; Department of Pathology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil., Rubin BK; Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA., Nakagawa NK; Department of Pathology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
Jazyk:	angličtina
Zdroj:	Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2014; Vol. 69 (12), pp. 867-70.
DOI:	10.6061/clinics/2014(12)13
Abstrakt:	Objectives: There is evidence that outdoor workers exposed to high levels of air pollution exhibit airway inflammation and increased airway symptoms. We hypothesized that these workers would experience increased airway symptoms and decreased nasal mucociliary clearance associated with their exposure to air pollution. Methods: In total, 25 non-smoking commercial motorcyclists, aged 18-44 years, were included in this study. These drivers work 8-12 hours per day, 5 days per week, driving on urban streets. Nasal mucociliary clearance was measured by the saccharine transit test; airway acidification was measured by assessing the pH of exhaled breath condensate; and airway symptoms were measured by the Sino-nasal Outcome Test-20 questionnaire. To assess personal air pollution exposure, the subjects used a passive-diffusion nitrogen dioxide (NO2) concentration-monitoring system during the 14 days before each assessment. The associations between NO2 and the airway outcomes were analyzed using the Mann-Whitney test and the Chi-Square test. Clinicaltrials.gov: NCT01976039. Results: Compared with clearance in healthy adult males, mucociliary clearance was decreased in 32% of the motorcyclists. Additionally, 64% of the motorcyclists had airway acidification and 92% experienced airway symptoms. The median personal NO2 exposure level was 75 mg/m3 for these subjects and a significant association was observed between NO2 and impaired mucociliary clearance (p=0.036). Conclusion: Non-smoking commercial motorcyclists exhibit increased airway symptoms and airway acidification as well as decreased nasal mucociliary clearance, all of which are significantly associated with the amount of exposure to air pollution.
Databáze:	MEDLINE
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