DENND1A gene variants in Bahraini Arab women with polycystic ovary syndrome.

Autor: Gammoh E; Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain., Arekat MR; Department of Internal Medicine, Arabian Gulf University, Manama, Bahrain., Saldhana FL; Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain., Madan S; Department of Obstetrics and Gynecology, Salmaniya Medical Complex, Manama, Bahrain., Ebrahim BH; Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain., Almawi WY; Department of Medical Biochemistry, Arabian Gulf University, Manama, Bahrain. Electronic address: wassim@agu.edu.bh.
Jazyk: angličtina
Zdroj: Gene [Gene] 2015 Apr 10; Vol. 560 (1), pp. 30-3. Date of Electronic Publication: 2015 Jan 24.
DOI: 10.1016/j.gene.2015.01.034
Abstrakt: Recent genome-wide association studies and replication analyses reported an association between variants of DENND1A gene and polycystic ovary syndrome (PCOS), mostly in Asians. We therefore examined whether the common DENND1A SNPs rs10818854, rs2479106, and rs10986105 are associated with PCOS in Bahraini Arab population. This case-control study involved 191 women with PCOS diagnosed according to the Rotterdam criteria, and 202 control women. SNP genotyping was performed by the allelic discrimination in real-time PCR. The outcome was that the minor allele frequencies of SNPs rs10818854, rs2479106, and rs10986105 were similar between women with PCOS and control women (P>0.05), even before correcting for multiple testing, and none of the tested DENND1A SNPs were associated with PCOS under co-dominant, dominant, or recessive genetic models. None of the tested DENND1A variants were associated with PCOS features (hirsutism, insulin sensitivity, menses pattern, free testosterone, and free androgen index). Taking common GTA haplotype as reference (OR=1.00), [rs10818854/rs2479106/rs10986105] 3-locus haplotype analysis demonstrated lack of association of any of the DENND1A haplotypes with PCOS, even before correcting for multiple testing. To conclude we demonstrated lack of association of DENND1A SNPs rs10818854, rs2479106, and rs10986105, previously associated with PCOS in Asians, with PCOS in Bahraini Arab women.
(Copyright © 2015 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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