The association between the 844ins68 polymorphism in the CBS gene and breast cancer.

Autor: Gallegos-Arreola MP; Laboratorio de Genética Molecular, División de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, México., Figuera-Villanueva LE; División de Genética, CIBO, CMNO, IMSS, Guadalajara, Jalisco, México., Ramos-Silva A; Laboratorio de Genética Molecular, División de Medicina Molecular, Centro de Investigación Biomédica de Occidente (CIBO), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, México ; Doctorado en Farmacología, CUCS, UdeG, Guadalajara, Jalisco, México., Salas-González E; UMAE, Hospital de Gineco-Obstetricia, CMNO, IMSS, Guadalajara, Jalisco, México., Puebla-Pérez AM; Laboratorio de Inmunofarmacología, CUCEI, UdeG, Guadalajara, Jalisco, México., Peralta-Leal V; Facultad de Medicina e Ingeniería en Sistemas Computacionales (FMeISC), Universidad Autónoma de Tamaulipas, Matamoros, Tamaulipas, México., García-Ortiz JE; División de Genética, CIBO, CMNO, IMSS, Guadalajara, Jalisco, México., Dávalos-Rodríguez IP; División de Genética, CIBO, CMNO, IMSS, Guadalajara, Jalisco, México., Zúñiga-González GM; Laboratorio de Mutagénesis, División de Medicina Molecular, CIBO, CMNO, IMSS, Guadalajara, Jalisco, México.
Jazyk: angličtina
Zdroj: Archives of medical science : AMS [Arch Med Sci] 2014 Dec 22; Vol. 10 (6), pp. 1214-24.
DOI: 10.5114/aoms.2014.47830
Abstrakt: Introduction: The cystathionine beta synthase (CBS) gene plays an important role in homocysteine metabolism because it catalyzes the first step of the transsulfuration pathway, during which homocysteine is converted to cystathionine. Polymorphisms of CBS have been associated with cancer.
Material and Methods: We examined the role of the 844ins68 polymorphism by comparing the genotypes of 371 healthy Mexican women with the genotypes of 323 Mexican women with breast cancer (BC).
Results: The observed genotype frequencies for controls and BC patients were 1% and 2% for Ins/Ins, 13% and 26% for W/Ins, and 86% and 72% for W/W, respectively. We found that the odds ratio (OR) was 2.2, with a 95% confidence interval (95% CI) of 1.5-3.3, p = 0.0001. The association was also evident when comparing the distribution of the W/Ins-Ins/Ins genotypes in patients in the following categories: 1) menopause and high γ-glutamyltransferase (GGT) levels (OR of 2.17, 95% CI: 1.17-4.26, p = 0.02), 2) chemotherapy response and high lactate dehydrogenase (LDH) levels (OR 2.2, 95% CI: 1.08-4.4, p = 0.027), 3) chemotherapy response and high GGT levels (OR 2.46, 95% CI: 1.2-4.8, p = 0.007), and 4) body mass index (BMI) and III-IV tumor stage (OR 3.2, 95% CI: 1.2-8.3, p = 0.013).
Conclusions: We conclude that the genotypes W/Ins-Ins/Ins of the 844ins68 polymorphism in the CBS gene contribute significantly to BC susceptibility in the analyzed sample from the Mexican population.
Databáze: MEDLINE
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