| Autor: |
Babji DV; Department of Oral Pathology and Microbiology, Maratha Mandal's NGH Institute of Dental Sciences, Belgaum, 590010 Karnataka India., Kale AD; Department of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences, Belgaum, 590010 Karnataka India., Hallikerimath SR; Department of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences, Belgaum, 590010 Karnataka India., Kotrashetti VS; Department of Oral Pathology and Microbiology, Maratha Mandal's NGH Institute of Dental Sciences, Belgaum, 590010 Karnataka India. |
| Jazyk: |
angličtina |
| Zdroj: |
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India [Indian J Otolaryngol Head Neck Surg] 2015 Mar; Vol. 67 (Suppl 1), pp. 21-8. Date of Electronic Publication: 2014 May 18. |
| DOI: |
10.1007/s12070-014-0730-6 |
| Abstrakt: |
Despite the advances in surgery, radiotherapy and chemotherapy the annual death for oral squamous cell carcinoma (OSCC) is rising rapidly. The carcinoma has propensity to develop in a field of cancerization. Clinically may it be apparently normal mucosa (ANM) adjacent to squamous cell carcinoma which harbours certain discrete molecular alteration which ultimately reflects in cellular morphology. Hence the aim of the study is to assess histomorphometric changes in ANM adjacent to OSCC. A prospective study was done on 30 each of histologically diagnosed cases OSCC, ANM at least 1 cm away from OSCC, and normal oral mucosa (NOM). Cellular and nuclear morphometric measurements were assessed on hematoxylin and eosin sections using image analysis software. Statistical analysis was done using analysis of variance test and Tukey's post hoc test. The present study showed significant changes in cellular and nuclear area in superficial and invasive island of OSCC compared to ANM. The basal cells of ANM showed significant decrease in cellular and nuclear areas and nuclear cytoplasmic ratio when compared to NOM. Histomorphometry definitely can differentiate OSCC form ANM and NOM. The basal cells of ANM showed significant alterations in cellular area, nuclear area and nuclear cytoplasmic area when compared to NOM suggesting change in the field and have high risk of malignant transformation. These parameters can be used as indicator of field cancerization. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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