Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings.

Autor: Gungor B; Department of Biological Sciences; Middle East Technical University ; Ankara, Turkey., Yagci FC; Department of Molecular Biology and Genetics Bilkent University ; Ankara, Turkey., Gursel I; Department of Molecular Biology and Genetics Bilkent University ; Ankara, Turkey., Gursel M; Department of Biological Sciences; Middle East Technical University ; Ankara, Turkey.
Jazyk: angličtina
Zdroj: Oncoimmunology [Oncoimmunology] 2014 Jul 03; Vol. 3 (7), pp. e950166. Date of Electronic Publication: 2014 Jul 03 (Print Publication: 2014).
DOI: 10.4161/21624011.2014.950166
Abstrakt: Type I interferon inducers may potentially be engineered to function as antiviral and anticancer agents, or alternatively, vaccine adjuvants, all of which may have clinical applications. We recently described a simple strategy to convert a Toll-like receptor 9 (TLR9) agonist devoid of interferon α (IFNα) stimulating activity into a robust Type I interferon inducer with potent vaccine adjuvant activity.
Databáze: MEDLINE