Clinical trials of helminth therapy in autoimmune diseases: rationale and findings.
| Autor: | Fleming JO; Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Weinstock JV |
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| Jazyk: | angličtina |
| Zdroj: | Parasite immunology [Parasite Immunol] 2015 Jun; Vol. 37 (6), pp. 277-92. |
| DOI: | 10.1111/pim.12175 |
| Abstrakt: | Some helminths are major human pathogens. Recently, however, increased understanding of the immunoregulatory responses induced by this class of parasites, in combination with epidemiologic and animal studies, suggests that helminths may have therapeutic potential in autoimmune diseases (AD) and other conditions. This article reviews the rationale for and results of clinical trials to test the safety and efficacy of helminth therapy in AD. Also discussed are future prospects for investigation and the possibility that helminth treatment may serve as a probe to help reveal the pathogenesis of AD. (© 2015 John Wiley & Sons Ltd.) |
| Databáze: | MEDLINE |
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