| Autor: |
Miller LC; Department of Chemistry and ‡Department of Molecular Biology, Princeton University , Washington Road, Princeton, New Jersey 08544, United States., O'Loughlin CT, Zhang Z, Siryaporn A, Silpe JE, Bassler BL, Semmelhack MF |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 2015 Feb 12; Vol. 58 (3), pp. 1298-306. Date of Electronic Publication: 2015 Feb 03. |
| DOI: |
10.1021/jm5015082 |
| Abstrakt: |
The development of new approaches for the treatment of antimicrobial-resistant infections is an urgent public health priority. The Pseudomonas aeruginosa pathogen, in particular, is a leading source of infection in hospital settings, with few available treatment options. In the context of an effort to develop antivirulence strategies to combat bacterial infection, we identified a series of highly effective small molecules that inhibit the production of pyocyanin, a redox-active virulence factor produced by P. aeruginosa. Interestingly, these new antagonists appear to suppress P. aeruginosa virulence factor production through a pathway that is independent of LasR and RhlR. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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