Human biomonitoring of aluminium after a single, controlled manual metal arc inert gas welding process of an aluminium-containing worksheet in nonwelders.

Autor: Bertram J; Medical Faculty, Institute for Occupational Medicine and Social Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany. jbertram@ukaachen.de., Brand P; Medical Faculty, Institute for Occupational Medicine and Social Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany., Hartmann L; Medical Faculty, Institute for Occupational Medicine and Social Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany., Schettgen T; Medical Faculty, Institute for Occupational Medicine and Social Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany., Kossack V; Medical Faculty, Institute for Occupational Medicine and Social Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany., Lenz K; ISF - Welding and Joining Institute, Aachen University of Technology, Pontstr. 49, 52062, Aachen, Germany., Purrio E; ISF - Welding and Joining Institute, Aachen University of Technology, Pontstr. 49, 52062, Aachen, Germany., Reisgen U; ISF - Welding and Joining Institute, Aachen University of Technology, Pontstr. 49, 52062, Aachen, Germany., Kraus T; Medical Faculty, Institute for Occupational Medicine and Social Medicine, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Jazyk: angličtina
Zdroj: International archives of occupational and environmental health [Int Arch Occup Environ Health] 2015 Oct; Vol. 88 (7), pp. 913-23. Date of Electronic Publication: 2015 Jan 18.
DOI: 10.1007/s00420-015-1020-7
Abstrakt: Purpose: Several existing field studies evaluate aluminium welding works but no thoroughly controlled exposure scenario for welding fume has been described yet. This study provides information about the uptake and elimination of aluminium from welding fumes under controlled conditions.
Methods: In the Aachen Workplace Simulation Laboratory, we are able to generate welding fumes of a defined particle mass concentration. We exposed 12, until then occupationally unexposed participants with aluminium-containing welding fumes of a metal inert gas (MIG) welding process of a total dust mass concentration of 2.5 mg/m(3) for 6 h. Room air filter samples were collected, and the aluminium concentration in air derived. Urine and plasma samples were collected directly before and after the 6-h lasting exposure, as well as after 1 and 7 days. Human biomonitoring methods were used to determine the aluminium content of the samples with high-resolution continuum source atomic absorption spectrometry.
Results: Urinary aluminium concentrations showed significant changes after exposure compared to preexposure levels (mean t(1) (0 h) 13.5 µg/L; mean t(2) (6 h) 23.5 µg/L). Plasma results showed the same pattern but pre-post comparison did not reach significance.
Conclusions: We were able to detect a significant increase of the internal aluminium burden of a single MIG aluminium welding process in urine, while plasma failed significance. Biphasic elimination kinetic can be observed. The German BAT of 60 µg/g creatinine was not exceeded, and urinary aluminium returned nearly to baseline concentrations after 7 days.
Databáze: MEDLINE
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