The vascular marker CD31 also highlights histiocytes and histiocyte-like cells within cutaneous tumors.

Autor:	Vanchinathan V; From the Departments of Pathology, Stanford University Medical Center, Stanford, CA., Mirzamani N, Kantipudi R; From the Departments of Pathology, Stanford University Medical Center, Stanford, CA., Schwartz EJ; From the Departments of Pathology, Stanford University Medical Center, Stanford, CA., Sundram UN; From the Departments of Pathology, Stanford University Medical Center, Stanford, CA. From the Departments of Dermatology, Stanford University Medical Center, Stanford, CA. sundram@stanford.edu.
Jazyk:	angličtina
Zdroj:	American journal of clinical pathology [Am J Clin Pathol] 2015 Feb; Vol. 143 (2), pp. 177-85; quiz 305.
DOI:	10.1309/AJCPRHM8CZH5EMFD
Abstrakt:	Objectives: While useful in diagnosing angiosarcomas, CD31 can also highlight histiocytes within soft tissue tumors and lead to errors in diagnosis. We sought to determine how often CD31 highlights cutaneous histiocytomas and histiocytoma mimics. Methods: We examined eight epithelioid cell histiocytomas (ECHs), 12 xanthogranulomas (XGs), nine cases of Langerhans cell histiocytosis (LCH), eight reticulohistiocytomas, 11 xanthomas, 29 atypical fibroxanthomas, nine granular cell tumors, four cases of angiolymphoid hyperplasia with eosinophilia, nine intradermal Spitz nevi, and nine angiosarcomas with antibodies directed against CD31, CD34, CD163, and factor VIII. Results: CD31 marked cells in three of 12 XGs, four of nine cases of LCH, one of eight reticulohistiocytomas, one of 11 xanthomas, 10 of 29 atypical fibroxanthomas, four of four cases of angiolymphoid hyperplasia with eosinophilia, nine of nine angiosarcomas, zero of nine granular cell tumors, and zero of eight ECHs. CD34 and factor VIII were negative in all nonvascular cases. Conclusions: Our results indicate that CD31 can mark lesional cells and imitate vascular tumors in cutaneous histiocytomas and histiocytoma mimics, an error that can be avoided by using a panel of antibodies. (Copyright© by the American Society for Clinical Pathology.)
Databáze:	MEDLINE
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