| Autor: |
Shim AR; Research Center for Cell Fate Control and College of Pharmacy, Sookmyung Women's University, Seoul 140-742., Dong GZ; Research Center for Cell Fate Control and College of Pharmacy, Sookmyung Women's University, Seoul 140-742., Lee HJ; Department of Natural Medicine Resources, Semyung University, Jecheon 390-711, Republic of Korea., Ryu JH; Research Center for Cell Fate Control and College of Pharmacy, Sookmyung Women's University, Seoul 140-742. |
| Jazyk: |
angličtina |
| Zdroj: |
Biomolecules & therapeutics [Biomol Ther (Seoul)] 2015 Jan; Vol. 23 (1), pp. 26-30. Date of Electronic Publication: 2015 Jan 01. |
| DOI: |
10.4062/biomolther.2014.095 |
| Abstrakt: |
Wnt/β-catenin signaling pathway was mutated in about 90% of the sporadic and hereditary colorectal cancers. The abnormally activated β-catenin increases the cancer cell proliferation, differentiation and metastasis through increasing the expression of its oncogenic target genes. In this study, we identified an inhibitor of β-catenin dependent Wnt pathway from rhizomes of Atractylodes macrocephala Koidzumi (Compositae). The active compound was purified by activity-guided purification and the structure was identified as 2,8-dimethyl-6-hydroxy-2-(4-methyl-3-pentenyl)-2H-chromene (atractylochromene, AC). AC suppressed β-catenin/T-cell factor transcriptional activity of HEK-293 reporter cells when they were stimulated by Wnt3a or inhibitor of glycogen synthase kinase-3β. AC down-regulated the nuclear level of β-catenin through the suppression of galectin-3 mediated nuclear translocation of β-catenin in SW-480 colon cancer cells. Furthermore, AC inhibits proliferation of colon cancer cell. Taken together, AC from A. macrocephala might be a potential chemotherapeutic agent for the prevention and treatment of human colon cancer. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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