| Autor: |
Kovach KM; Advanced Platform Technology Center (APT Center), Louis Stokes Cleveland VA Medical Center, Cleveland, OH 44106, USA., LaBarbera MA, Moyer MC, Cmolik BL, van Lunteren E, Sen Gupta A, Capadona JR, Potkay JA |
| Jazyk: |
angličtina |
| Zdroj: |
Lab on a chip [Lab Chip] 2015 Mar 07; Vol. 15 (5), pp. 1366-75. |
| DOI: |
10.1039/c4lc01284d |
| Abstrakt: |
Despite the promising potential of microfluidic artificial lungs, current designs suffer from short functional lifetimes due to surface chemistry and blood flow patterns that act to reduce hemocompatibility. Here, we present the first microfluidic artificial lung featuring a hemocompatible surface coating and a biomimetic blood path. The polyethylene-glycol (PEG) coated microfluidic lung exhibited a significantly improved in vitro lifetime compared to uncoated controls as well as consistent and significantly improved gas exchange over the entire testing period. Enabled by our hemocompatible PEG coating, we additionally describe the first extended (3 h) in vivo demonstration of a microfluidic artificial lung. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
