Bilateral coherence between motor cortices and subthalamic nuclei in patients with Parkinson's disease.

Autor: Kato K; Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan; Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Kanagawa, Japan., Yokochi F; Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan. Electronic address: fyokochi-tmnh@umin.net., Taniguchi M; Department of Neurosurgery, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan., Okiyama R; Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan., Kawasaki T; Department of Neurosurgery, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan., Kimura K; Department of Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan., Ushiba J; Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Kanagawa, Japan.
Jazyk: angličtina
Zdroj: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2015 Oct; Vol. 126 (10), pp. 1941-50. Date of Electronic Publication: 2014 Dec 19.
DOI: 10.1016/j.clinph.2014.12.007
Abstrakt: Objective: It has been suggested that abnormal synchronization and oscillation of neuronal activity in the subthalamic nucleus (STN) is associated with sensorimotor dysfunction in Parkinson's disease (PD). We investigated the bilateral subcortico-cortical functional coupling in PD patients.
Methods: We simultaneously recorded local field potentials from the bilateral STN using electrodes inserted for deep brain stimulation and electroencephalograms from the bilateral motor cortices (MCx) in 11 patients at rest, and analyzed their coherences and causalities.
Results: Significant coherence in the sub-beta and beta frequency bands was simultaneously observed between the STN and contralateral STN (STN-cSTN), the STN and ipsilateral MCx (STN-iMCx), and the STN and contralateral MCx (STN-cMCx). In each patient, the frequency of the peak STN-cSTN coherence was similar to that of the peak STN-iMCx and STN-cMCx coherence. The causality between the STN and MCx was strongest in the one-way direction from the MCx to the ipsilateral STN.
Conclusions: Abnormal oscillations in the STN in the sub-beta and beta bands were functionally coupled among bilateral STN and MCx at the eigen-frequency in individual patients with PD.
Significance: Synchronized activity through cortico-subcortical transmission may have an important role in the pathophysiology of PD.
(Copyright © 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.)
Databáze: MEDLINE
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