Chirality-selected phase behaviour in ionic polypeptide complexes.

Autor: Perry SL; Institute for Molecular Engineering, University of Chicago, Chicago, Illinois 60637, USA., Leon L; 1] Institute for Molecular Engineering, University of Chicago, Chicago, Illinois 60637, USA [2] Argonne National Laboratory, Argonne, Illinois 60439, USA., Hoffmann KQ; 1] Institute for Molecular Engineering, University of Chicago, Chicago, Illinois 60637, USA [2] Department of Chemical Engineering, University of Wisconsin, Madison, Wisconsin 53706, USA., Kade MJ; 1] Institute for Molecular Engineering, University of Chicago, Chicago, Illinois 60637, USA [2] Argonne National Laboratory, Argonne, Illinois 60439, USA., Priftis D; Institute for Molecular Engineering, University of Chicago, Chicago, Illinois 60637, USA., Black KA; Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720, USA., Wong D; Institute for Molecular Engineering, University of Chicago, Chicago, Illinois 60637, USA., Klein RA; Institute for Molecular Engineering, University of Chicago, Chicago, Illinois 60637, USA., Pierce CF 3rd; Institute for Molecular Engineering, University of Chicago, Chicago, Illinois 60637, USA., Margossian KO; Institute for Molecular Engineering, University of Chicago, Chicago, Illinois 60637, USA., Whitmer JK; 1] Institute for Molecular Engineering, University of Chicago, Chicago, Illinois 60637, USA [2] Argonne National Laboratory, Argonne, Illinois 60439, USA., Qin J; Institute for Molecular Engineering, University of Chicago, Chicago, Illinois 60637, USA., de Pablo JJ; 1] Institute for Molecular Engineering, University of Chicago, Chicago, Illinois 60637, USA [2] Argonne National Laboratory, Argonne, Illinois 60439, USA., Tirrell M; 1] Institute for Molecular Engineering, University of Chicago, Chicago, Illinois 60637, USA [2] Argonne National Laboratory, Argonne, Illinois 60439, USA.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2015 Jan 14; Vol. 6, pp. 6052. Date of Electronic Publication: 2015 Jan 14.
DOI: 10.1038/ncomms7052
Abstrakt: Polyelectrolyte complexes present new opportunities for self-assembled soft matter. Factors determining whether the phase of the complex is solid or liquid remain unclear. Ionic polypeptides enable examination of the effects of stereochemistry on complex formation. Here we demonstrate that chirality determines the state of polyelectrolyte complexes, formed from mixing dilute solutions of oppositely charged polypeptides, via a combination of electrostatic and hydrogen-bonding interactions. Fluid complexes occur when at least one of the polypeptides in the mixture is racemic, which disrupts backbone hydrogen-bonding networks. Pairs of purely chiral polypeptides, of any sense, form compact, fibrillar solids with a β-sheet structure. Analogous behaviour occurs in micelles formed from polypeptide block copolymers with polyethylene oxide, where assembly into aggregates with either solid or fluid cores, and eventually into ordered phases at high concentrations, is possible. Chirality is an exploitable tool for manipulating material properties in polyelectrolyte complexation.
Databáze: MEDLINE
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