Cytomorphological characteristics of low-grade papillary urothelial carcinoma for differential diagnosis from benign papillary urothelial lesions: logistic regression analysis in SurePath(™) liquid-based voided urine cytology.

Autor: Chung YR; Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea., Won JK; Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea., Park IA; Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea., Moon KC; Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea., Chung SY; Department of Pathology, Cancer Center, Dongnam Institute of Radiological and Medical Sciences (DIRAMS), Busan, South Korea., Lee K; Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea., Ryu HS; Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Jazyk: angličtina
Zdroj: Cytopathology : official journal of the British Society for Clinical Cytology [Cytopathology] 2016 Apr; Vol. 27 (2), pp. 83-90. Date of Electronic Publication: 2015 Jan 12.
DOI: 10.1111/cyt.12230
Abstrakt: Objective: The diagnosis of low-grade papillary urothelial carcinoma (LGPUC) in urine cytology specimens is challenging because of its subtle, minimally atypical findings. Furthermore, as SurePath(™) liquid-based cytology (LBC) is becoming a widely used method in urine cytology, the inevitable cytomorphological alterations resulting from this technique call for new morphological diagnostic criteria in LGPUC.
Methods: Logistic regression analysis was carried out on SurePath slides from surgically proven voided urine specimens. The study was designed to include a test set (n = 141) and a validation set (n = 61), and evaluated significant discriminative parameters between LGPUC and benign papillary urothelial neoplasm (BPUN).
Results: Of the seven cytological findings that were found to have statistical significance in univariate analysis, five were found to be independent variables: loss of polarity of papillaroid clusters, irregular contours, absence of columnar cells, hobnail features and hyperchromasia. These independent variables had an area under the curve (AUC) of 0.781.
Conclusions: The distinctive cytological criteria identified above may prove to be helpful in cases in which other conventional criteria for LGPUC are insufficient for diagnosis.
(© 2015 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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