Gut microbiota. Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation.

Autor: Cullen TW; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520, USA. Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06520, USA., Schofield WB; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520, USA. Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06520, USA., Barry NA; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520, USA. Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06520, USA., Putnam EE; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520, USA. Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06520, USA., Rundell EA; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520, USA., Trent MS; Department of Molecular Biosciences and Institute of Cell and Molecular Biology, University of Texas, Austin, TX 78712, USA., Degnan PH; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA., Booth CJ; Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA., Yu H; Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA., Goodman AL; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520, USA. Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06520, USA. andrew.goodman@yale.edu.
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2015 Jan 09; Vol. 347 (6218), pp. 170-5.
DOI: 10.1126/science.1260580
Abstrakt: Resilience to host inflammation and other perturbations is a fundamental property of gut microbial communities, yet the underlying mechanisms are not well understood. We have found that human gut microbes from all dominant phyla are resistant to high levels of inflammation-associated antimicrobial peptides (AMPs) and have identified a mechanism for lipopolysaccharide (LPS) modification in the phylum Bacteroidetes that increases AMP resistance by four orders of magnitude. Bacteroides thetaiotaomicron mutants that fail to remove a single phosphate group from their LPS were displaced from the microbiota during inflammation triggered by pathogen infection. These findings establish a mechanism that determines the stability of prominent members of a healthy microbiota during perturbation.
(Copyright © 2015, American Association for the Advancement of Science.)
Databáze: MEDLINE
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