The high-affinity human IgG receptor Fc gamma receptor I (FcγRI) is not associated with vascular leakage of dengue.

Autor: Mohamad Zamberi Z; Institute of Molecular Medical Biotechnology (IMMB), Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysia. zaiharina@gmail.com., Zakaria Z; Institute of Molecular Medical Biotechnology (IMMB), Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysia. zuraihan_zakaria@yahoo.com., Abdul Aziz AT; Institute of Molecular Medical Biotechnology (IMMB), Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysia. thalhahaziz@salam.uitm.edu.my., Heng BS; Hospital Sungai Buloh, Jalan Hospital, 47000, Sungai Buloh, Selangor Darul Ehsan, Malaysia. limsim7@yahoo.com., Zaid M; Hospital Sungai Buloh, Jalan Hospital, 47000, Sungai Buloh, Selangor Darul Ehsan, Malaysia. maxx_liza@yahoo.co.uk., Chong CL; Hospital Sungai Buloh, Jalan Hospital, 47000, Sungai Buloh, Selangor Darul Ehsan, Malaysia. chrislee@moh.gov.my., Noor FM; Microbiology Unit, Centre for Pathology Diagnostic and Research Laboratories (CPDRL), Level 1, Clinical Training Centre (CTC), Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Jalan Hospital, 47000, Sungai Buloh, Selangor, Malaysia. fadzi456@salam.uitm.edu.my.; Drug and Discovery Research Core, Universiti Teknologi MARA, Shah Alam, 40450, Shah Alam, Selangor, Malaysia. fadzi456@salam.uitm.edu.my., Abu Bakar S; Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. sazaly@um.edu.my.; Tropical Infectious Disease Research and Education Centre, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. sazaly@um.edu.my., Boon Peng H; Institute of Molecular Medical Biotechnology (IMMB), Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000, Sungai Buloh, Selangor, Malaysia. hoh.boonpeng@gmail.com.; Drug and Discovery Research Core, Universiti Teknologi MARA, Shah Alam, 40450, Shah Alam, Selangor, Malaysia. hoh.boonpeng@gmail.com.
Jazyk: angličtina
Zdroj: Journal of negative results in biomedicine [J Negat Results Biomed] 2015 Jan 08; Vol. 14, pp. 1. Date of Electronic Publication: 2015 Jan 08.
DOI: 10.1186/s12952-014-0020-6
Abstrakt: Background: Dengue is a major public health problem in many tropical and sub-tropical countries. Vascular leakage and shock are identified as the major causes of deaths in patients with severe dengue. Studies have suggested the potential role of Fc gamma receptors I (FcγRI) in the pathogenesis of dengue. We hypothesized that the circulating level of Fcγ receptor I could potentially be used as an indicator in assisting early diagnosis of severe dengue.
Results: A selected cohort of 66 dengue patients including 42 dengue with signs of vascular leakage, and 24 dengue without signs of vascular leakage were identified and were afterwards referred to as 'cases' and 'controls' respectively. Thirty seven normal healthy controls were also recruited in this study. The circulating level of FcγRI was quantified from the serum using enzyme-link immunosorbent assay (ELISA). The levels of FcγRI in both groups of patients with and without vascular leakage were found to be significantly higher than the normal healthy controls (P < 0.001). However, there was no significant difference found between patients with vascular leakage and those without vascular leakage (p = 0.777).
Conclusion: We suggest that FcγRI is not associated with the vascular leakage in dengue. However, further studies are necessary to delineate the role of FcγRI in antibody-dependent enhancement (ADE) mechanism.
Databáze: MEDLINE
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