| Autor: |
González CS; Department of Physiological Sciences, Faculty of Biological and Natural Sciences, University of Concepcion, Chile., Norris BC, Concha JB, Contreras GM |
| Jazyk: |
angličtina |
| Zdroj: |
General pharmacology [Gen Pharmacol] 1989; Vol. 20 (6), pp. 767-70. |
| DOI: |
10.1016/0306-3623(89)90327-3 |
| Abstrakt: |
1. This study was undertaken to demonstrate the facilitatory effects of 4-aminopyridine on transmitter release in the toad skin preparation. 2. A dose-dependent increase in the bioelectric parameters was found. 3. This effect was blocked by propranolol and by verapamil but not by dibenamine, and was mimicked by the calcium ionophore A-23187 but not by potassium channel blockers. 4. These results support the hypothesis that 4-aminopyridine increases presynaptic nerve terminal permeability of calcium and thus the release of noradrenaline. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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