Extracellular vesicles as carriers of microRNA, proteins and lipids in tumor microenvironment.

Autor:	Penfornis P; Department of Biochemistry and Cancer Institute, University of Mississippi Medical Center, Jackson, MS., Vallabhaneni KC; Department of Biochemistry and Cancer Institute, University of Mississippi Medical Center, Jackson, MS., Whitt J; Department of Biochemistry and Cancer Institute, University of Mississippi Medical Center, Jackson, MS., Pochampally R; Department of Biochemistry and Cancer Institute, University of Mississippi Medical Center, Jackson, MS.
Jazyk:	angličtina
Zdroj:	International journal of cancer [Int J Cancer] 2016 Jan 01; Vol. 138 (1), pp. 14-21. Date of Electronic Publication: 2015 Jan 23.
DOI:	10.1002/ijc.29417
Abstrakt:	In recent years, the knowledge about the control of tumor microenvironment has increased and emerged as an important player in tumorigenesis. The role of normal stromal cells in the tumor initiation and progression has brought our vision in to the forefront of cell-to-cell communication. In this review, we focus on the mechanism of communication between stromal and tumor cells, which is based on the exchange of extracellular vesicles (EVs). We describe several, evergrowing, pieces of evidence that EVs transfer messages through their miRNA, lipid, protein and nucleic acid contents. A better understanding of this sophisticated method of communication between normal cancer cells may lead to developing novel approaches for personalized diagnostics and therapeutics. (© 2015 UICC.)
Databáze:	MEDLINE
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