The effect of acute alcohol intoxication on gut wall integrity in healthy male volunteers; a randomized controlled trial.

Autor: de Jong WJ; Department of Surgery, University Medical Center Groningen, The Netherlands. Electronic address: W.J.J.de.Jong@UMCG.nl., Cleveringa AM; Department of Surgery, University Medical Center Groningen, The Netherlands., Greijdanus B; Department of Hospital and Clinical Pharmacy, University Medical Center Groningen, The Netherlands., Meyer P; Department of Anesthesiology, University Medical Center Groningen, The Netherlands., Heineman E; Department of Surgery, University Medical Center Groningen, The Netherlands., Hulscher JB; Department of Surgery, University Medical Center Groningen, The Netherlands.
Jazyk: angličtina
Zdroj: Alcohol (Fayetteville, N.Y.) [Alcohol] 2015 Feb; Vol. 49 (1), pp. 65-70. Date of Electronic Publication: 2014 Dec 09.
DOI: 10.1016/j.alcohol.2014.09.033
Abstrakt: The aim of the study is to determine the effect of acute alcohol consumption on enterocytes. Chronic alcohol consumption has been known to induce a decrease in gut wall integrity in actively drinking alcoholics and patients with alcohol-induced liver disease. Data on the extent of the damage induced by acute alcohol consumption in healthy human beings is scarce. Studies show that heavy incidental alcohol consumption is a growing problem in modern society. Data on this matter may provide insights into the consequences of this behavior for healthy individuals. In a randomized clinical trial in crossover design, 15 healthy volunteers consumed water one day and alcohol the other. One blood sample was collected pre-consumption, five every hour post-consumption, and one after 24 h. Intestinal fatty acid binding protein (I-FABP) was used as a marker for enterocyte damage. Liver fatty acid binding protein (L-FABP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT) were used as markers for hepatocyte damage. Lipopolysaccharide binding protein (LBP) and soluble CD14 (sCD14) were used as a measure of translocation. Interleukin-6 (IL-6) was used to assess the acute inflammatory response to endotoxemia. Alcohol consumption caused a significant increase in serum I- and L-FABP levels, compared to water consumption. Levels increased directly post-consumption and decreased to normal levels within 4 h. LBP, sCD14, and IL-6 levels were not significantly higher in the alcohol group. Moderate acute alcohol consumption immediately damages the enterocyte but does not seem to cause endotoxemia.
(Copyright © 2015 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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