| Autor: |
Tarr KL; Department of Medical Microbiology and Immunology, College of Medicine, Ohio State University, Columbus 43210., Glaser R |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medical virology [J Med Virol] 1989 Sep; Vol. 29 (1), pp. 47-52. |
| DOI: |
10.1002/jmv.1890290109 |
| Abstrakt: |
It is important to know whether there are variants of Epstein-Barr virus (EBV) with biological properties that are different from the prototype viruses that have been studied in detail, such as P3HR-1 and B95-8. We have studied an EBV isolate derived from a nasopharyngeal carcinoma (NPC) tumor, designated NPC-EBV. We have examined the target B lymphocytes infected and growth-transformed with NPC-EBV as compared with two common EBV isolates, B95-8 and AG876 EBV, for stage of maturation using antibodies to several immunoglobulin chains. Typing of the NPC-EBV transformed lymphoblastoid cell lines revealed the predilection of the NPC-EBV isolate to infect immature B lymphocytes. This was not the case for the B95-8 and AG876 isolates. The reason for the predilection of NPC-EBV for immature B lymphocytes remains to be explored further. However, these results may be important in understanding the pathophysiology of EBV-associated diseases. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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