[The correcting effects of dihydroquercetin in cerebral ischemia-reperfusion injury].

Autor: Maksimovich NY; Grodno State Medical University., Dremza IK; Grodno State Medical University., Troian EI; Grodno State Medical University., Maksimovich YN; Grodno State Medical University., Borodinskiĭ AN; Grodno State Medical University.
Jazyk: ruština
Zdroj: Biomeditsinskaia khimiia [Biomed Khim] 2014 Nov-Dec; Vol. 60 (6), pp. 643-50.
DOI: 10.18097/pbmc20146006643
Abstrakt: The dynamics of changes in the mitochondrial respiratory function, changes in the parameters of carbohydrate metabolism and some parameters of oxidative stress in the brain tissue have been investigated under conditions of ischemia-reperfusion and administration of dihydroquercetin. Dihydroquercetin (65 mg/kg) was administered per os 1 h before modeling of ischemia-reperfusion. Studies were carried 1 h after reperfusion. It was found that administration of dihydroquercetin caused a corrective effect to impairments of the respiratory function of mitochondria, indicators of carbohydrate metabolism and parameters of oxidative stress induced by ischemia-reperfusion.
Databáze: MEDLINE