Sol-gel encapsulation of biomolecules and cells for medicinal applications.

Autor: Wang X, Ahmed NB, Alvarez GS, Tuttolomondo MV, Hélary C, Desimone MF, Coradin T; Chimie de la Matiere Condensee, College de France, 11 place Marcelin Berthelot, 75005 Paris, France. thibaud.coradin@upmc.fr.
Jazyk: angličtina
Zdroj: Current topics in medicinal chemistry [Curr Top Med Chem] 2015; Vol. 15 (3), pp. 223-44.
DOI: 10.2174/1568026614666141229112734
Abstrakt: The sol-gel process provides a robust and versatile technology for the immobilization of biologicals. A wide range of inorganic, composites and hybrid materials can be prepared to encapsulate molecular drugs, proteins, antibodies/antigens, enzymes, nucleic acids, prokaryotic and eukaryotic cells into bulk gels, particles and films. This review describes the applications of sol-gel encapsulation relevant to medicinal chemistry focusing on the recent development of biosensors as well as systems for production, screening and delivery of bioactive compounds and biomaterials.
Databáze: MEDLINE