Syntheses of isoxazoline-carbocyclic nucleosides and their antiviral evaluation: a standard protocol.

Autor: Quadrelli P; Dipartimento di Chimica, Università degli Studi di Pavia, Viale Taramelli 12, 27100 Pavia, Italy., Vazquez Martinez N; Dipartimento di Chimica, Università degli Studi di Pavia, Viale Taramelli 12, 27100 Pavia, Italy., Scrocchi R; Dipartimento di Chimica, Università degli Studi di Pavia, Viale Taramelli 12, 27100 Pavia, Italy., Corsaro A; Dipartimento di Scienze del Farmaco, Università degli Studi di Catania, Viale A. Doria 8, 95125 Catania, Italy., Pistarà V; Dipartimento di Scienze del Farmaco, Università degli Studi di Catania, Viale A. Doria 8, 95125 Catania, Italy.
Jazyk: angličtina
Zdroj: TheScientificWorldJournal [ScientificWorldJournal] 2014; Vol. 2014, pp. 492178. Date of Electronic Publication: 2014 Oct 30.
DOI: 10.1155/2014/492178
Abstrakt: The current synthesis of racemic purine and pyrimidine isoxazoline-carbocyclic nucleosides is reported, detailing the key-steps for standard and reliable preparations. Improved yields were obtained by the proper tuning of the single synthetic steps, opening the way for the preparation of a variety of novel compounds. Some of the obtained compounds were also evaluated against a wide variety of DNA and RNA viruses including HIV. No specific antiviral activity was observed in the cases at hand. Novel compounds were prepared for future biological tests.
Databáze: MEDLINE
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