[Solid pseudopapillary tumors of the pancreas: clinical and morphological characteristics, specific features of their immunophenotype, and diagnostic problems].

Autor:	Gurevich LE, Kazantseva IA, Sokolova IN, Korsakova NA, Kuzovleva EI, Chistiakova OA, Aver'ianova IuA, Egorov AV, Britvin TA, Dolzhikov AA, Egorov VI
Jazyk:	ruština
Zdroj:	Arkhiv patologii [Arkh Patol] 2014 Sep-Oct; Vol. 76 (5), pp. 44-54.
Abstrakt:	Objective: To analyze 60 cases of solid pseudopapillary tumors (SPTs) of the pancreas, to reveal their most characteristic clinical and morphological features, and to study their possible histogenesis. Material and Methods: Sixty cases of SPTs of the pancreas underwent clinical, morphological, and immunohistochemical (IHC) examinations; a comparison group consisted of 86 pancreatic tumors of other histogenesis. Results: It has been shown for the first time that SPTs are characterized by the nuclear expression of claudin 3 and the cytoplasmic expression of claudin 7. It has been also ascertained that the aberrant perinuclear (dot-like) expression of CD99 is a unique feature of these tumors. Conclusion: SPTs of the pancreas are distinguished by a diversity of clinical manifestations and morphological features, but have a unique immunophenotype, which can differentiate them from other types of pancreatic tumors.
Databáze:	MEDLINE
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