Brain and arterial abnormalities following prenatal X-ray irradiation in mice assessed by magnetic resonance imaging and angiography.

Autor: Saito S; Division of Health Sciences, Department of Medical Engineering, Osaka University Graduate School of Medicine; Center for Information and Neural Networks (CiNet), National Institute of Information and Communications Technology., Sawada K, Mori Y, Yoshioka Y, Murase K
Jazyk: angličtina
Zdroj: Congenital anomalies [Congenit Anom (Kyoto)] 2015 May; Vol. 55 (2), pp. 103-6.
DOI: 10.1111/cga.12101
Abstrakt: The present study aimed to quantitatively characterize changes in the whole brain and arterial morphology in response to prenatal ionizing irradiation. Magnetic resonance imaging (MRI) and angiography (MRA) were used to evaluate brain and arterial abnormalities in 8-week-old male mice prenatally exposed to X-ray radiation at a dose of 0.5 or 1.0 Gy on embryonic day (E) 13. Irradiated mice demonstrated decreased brain volume, increased ventricular volume, and arterial malformation. Additionally, MRA signal intensity and arterial thickness in the anterior cerebral artery, middle cerebral artery, and basilar artery were lower in radiation-exposed mice than in control mice. MRI and MRA are useful tools for assessing brain and arterial abnormalities after prenatal exposure to radiation.
(© 2014 Japanese Teratology Society.)
Databáze: MEDLINE
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