Magnetic resonance sialography of the parotid glands in chronic hepatitis C virus patients with and without vasculitis.

Autor: Shahin AA; Department of Rheumatology and Rehabilitation, Faculty of Medicine, Cairo University, Cairo, Egypt., Hussein H; Department of Rheumatology and Rehabilitation, Faculty of Medicine, Cairo University, Cairo, Egypt., Gaber W; Department of Rheumatology and Rehabilitation, Faculty of Medicine, Cairo University, Cairo, Egypt., Elbaz T; Department of Endemic Hepatogastroenterology, Faculty of Medicine, Cairo University, Cairo, Egypt., Salah El Din LA; Department of Radiology, Faculty of Medicine, Cairo University, Cairo, Egypt.
Jazyk: angličtina
Zdroj: International journal of rheumatic diseases [Int J Rheum Dis] 2017 Mar; Vol. 20 (3), pp. 376-382. Date of Electronic Publication: 2014 Dec 23.
DOI: 10.1111/1756-185X.12493
Abstrakt: Aim: Hepatitis C virus (HCV) is sialotropic. The pathogenesis of sicca manifestations in patients with chronic HCV infection is not fully understood. We aimed to detect changes in magnetic resonance sialography (MRS) of HCV patients with and without vasculitis.
Method: We studied 32 HCV patients (19 female, mean age 48.8 ± 10.3 years) and 20 age- and gender-matched healthy controls. Half of the patients had vasculitis. Demographic, clinical and serological data were prospectively evaluated. In patients with vasculitis, the disease activity was assessed by the Birmingham Vasculitis Activity Score (BVAS). MRS was performed on all patients and controls.
Results: Abnormal MRS was found in 25% of patients, (6/16 and 2/16 in patients with and without vasculitis, respectively). Among patients with vasculitis, those with abnormal MRS had longer disease duration, higher leukocytic and lymphocytic counts and more frequent cryoglobulinemia (P < 0.01, P < 0.001, P < 0.001 and P < 0.008, respectively), while BVAS scores were not significantly different.
Conclusion: Among HCV patients with vasculitis, longer disease duration and cryoglobulinemia were associated with abnormal findings on MRS. To confirm our results, we propose larger-scale, multicentre studies with longer evaluation periods.
(© 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.)
Databáze: MEDLINE
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