Differential profile in inflammatory and mineral metabolism biomarkers in patients with ischemic heart disease without classical coronary risk factors.

Autor: Pello AM; Department of Cardiology, IIS-Fundación Jiménez Díaz, Madrid, Spain., Cristóbal C; Department of Cardiology, Hospital de Fuenlabrada, Fuenlabrada, Spain; Rey Juan Carlos University, Alcorcón, Spain., Tarín N; Department of Cardiology, Hospital Universitario de Móstoles, Móstoles, Spain., Huelmos A; Department of Cardiology, Hospital Universitario Fundación Alcorcón, Alcorcón, Spain., Aceña Á; Department of Cardiology, IIS-Fundación Jiménez Díaz, Madrid, Spain., Carda R; Department of Cardiology, IIS-Fundación Jiménez Díaz, Madrid, Spain., González-Casaus ML; Laboratory of Nephrology and Mineral Metabolism, Hospital Gómez-Ulla, Madrid, Spain., Alonso J; Department of Cardiology, Hospital de Fuenlabrada, Fuenlabrada, Spain; Rey Juan Carlos University, Alcorcón, Spain., Lorenzo Ó; Laboratory of Vascular Pathology, IIS-Fundación Jiménez Díaz, Madrid, Spain; Autónoma University, Madrid, Spain., Blanco-Colio L; Laboratory of Vascular Pathology, IIS-Fundación Jiménez Díaz, Madrid, Spain., Martín-Ventura JL; Laboratory of Vascular Pathology, IIS-Fundación Jiménez Díaz, Madrid, Spain; Autónoma University, Madrid, Spain., Franco Peláez JA; Department of Cardiology, IIS-Fundación Jiménez Díaz, Madrid, Spain., Mahíllo-Fernández I; Department of Epidemiology, IIS-Fundación Jiménez Díaz, Madrid, Spain., Farré J; Department of Cardiology, IIS-Fundación Jiménez Díaz, Madrid, Spain; Autónoma University, Madrid, Spain., López-Bescós L; Rey Juan Carlos University, Alcorcón, Spain., Egido J; Laboratory of Vascular Pathology, IIS-Fundación Jiménez Díaz, Madrid, Spain; Autónoma University, Madrid, Spain; Department of Nephrology, IIS-Fundación Jiménez Díaz, Madrid, Spain; CIBERDEM, Madrid, Spain., Tuñón J; Department of Cardiology, IIS-Fundación Jiménez Díaz, Madrid, Spain; Laboratory of Vascular Pathology, IIS-Fundación Jiménez Díaz, Madrid, Spain; Autónoma University, Madrid, Spain. Electronic address: jtunon@secardiologia.es.
Jazyk: angličtina
Zdroj: Journal of cardiology [J Cardiol] 2015 Jul; Vol. 66 (1), pp. 22-7. Date of Electronic Publication: 2014 Dec 19.
DOI: 10.1016/j.jjcc.2014.11.006
Abstrakt: Background: Patients with coronary heart disease (CHD) without classical cardiovascular risk factors (CRFs) are uncommon, and their profile has not been thoroughly studied. In CHD patients, we have assessed the differences in several biomarkers between those with and without CRF.
Methods: We studied 704 patients with CHD, analyzing plasma levels of biomarkers related to inflammation, thrombosis, renal damage, and heart failure: high-sensitivity C-reactive protein (hs-CRP), monocyte chemoattractant protein-1 (MCP-1), galectin-3, N-terminal fragment of brain natriuretic peptide (NT-pro-BNP), calcidiol (vitamin D metabolite), fibroblast growth factor-23 (FGF-23), parathormone, and phosphate.
Results: Twenty patients (2.8%) exhibited no CRFs. Clinical variables were well balanced in both groups, with the logical exceptions of no use of antidiabetic drugs, lower triglyceride and glucose, and higher high-density lipoprotein cholesterol in no-CRF patients. No-CRF patients showed lower hs-CRP (2.574±3.120 vs. 4.554±9.786mg/L; p=0.018), MCP-1 (114.75±36.29 vs. 143.56±65.37pg/ml; p=0.003), and FGF-23 (79.28±40.22 vs. 105.17±156.61RU/ml; p=0.024), and higher calcidiol (23.66±9.12 vs. 19.49±8.18ng/ml; p=0.025) levels. At follow-up, 10.0% vs. 11.0% patients experienced acute ischemic event, heart failure, or death in the non-CRF and CRF groups, respectively (p=0.815, log-rank test). The limited number of non-CRF patients may have influenced this finding. A Cox regression analysis in the whole population showed that high calcidiol, and low MCP-1 and FGF-23 plasma levels are associated with a better prognosis.
Conclusions: CHD patients without CRFs show a favorable biomarker profile in terms of inflammation and mineral metabolism. Further studies are needed to investigate whether this difference translates into a better prognosis.
(Copyright © 2014 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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