Glyoxylate, a new marker metabolite of type 2 diabetes.

Autor: Nikiforova VJ; Metanomics Health GmbH, 10589 Berlin, Germany ; Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, Moscow 127276, Russia., Giesbertz P; ZIEL Research Center for Nutrition and Food Sciences, Biochemistry Unit, Technische Universität München, 85354 Freising, Germany., Wiemer J; metanomics GmbH, 10589 Berlin, Germany ; Thermo Fisher Scientific, Clinical Diagnostics, BRAHMS GmbH, 16761 Hennigsdorf, Germany., Bethan B; metanomics GmbH, 10589 Berlin, Germany., Looser R; metanomics GmbH, 10589 Berlin, Germany., Liebenberg V; Metanomics Health GmbH, 10589 Berlin, Germany ; Thermo Fisher Scientific, Clinical Diagnostics, BRAHMS GmbH, 16761 Hennigsdorf, Germany., Ruiz Noppinger P; Metanomics Health GmbH, 10589 Berlin, Germany ; Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany., Daniel H; ZIEL Research Center for Nutrition and Food Sciences, Biochemistry Unit, Technische Universität München, 85354 Freising, Germany., Rein D; Metanomics Health GmbH, 10589 Berlin, Germany.
Jazyk: angličtina
Zdroj: Journal of diabetes research [J Diabetes Res] 2014; Vol. 2014, pp. 685204. Date of Electronic Publication: 2014 Nov 27.
DOI: 10.1155/2014/685204
Abstrakt: Type 2 diabetes (T2D) is characterized by a variety of metabolic impairments that are closely linked to nonenzymatic glycation reactions of proteins and peptides resulting in advanced glycation end-products (AGEs). Reactive aldehydes derived from sugars play an important role in the generation of AGEs. Using metabolite profiling to characterize human plasma from diabetic versus nondiabetic subjects we observed in a recent study that the reactive aldehyde glyoxylate was increased before high levels of plasma glucose, typical for a diabetic condition, could be measured. Following this observation, we explored the relevance of increased glyoxylate in diabetic subjects and in diabetic C57BLKS/J-Lepr (db/db (-/-)) mice in the pathophysiology of diabetes. A retrospective study using samples of long-term blood donors revealed that glyoxylate levels unlike glucose levels became significantly elevated up to 3 years prior to diabetes diagnosis (difference to control P = 0.034). Elevated glyoxylate levels impact on newly identified mechanisms linking hyperglycemia and AGE production with diabetes-associated complications such as diabetic nephropathy. Glyoxylate in its metabolic network may serve as an early marker in diabetes diagnosis with predictive qualities for associated complications and as potential to guide the development of new antidiabetic therapies.
Databáze: MEDLINE
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