| Autor: |
Maxwell CA; CSIRO, Division of Animal Production, Blacktown, Australia., Rintoul AJ, Foldes A, Downing JA, Scaramuzzi RJ, Carter NB |
| Jazyk: |
angličtina |
| Zdroj: |
Neuroendocrinology [Neuroendocrinology] 1989 Sep; Vol. 50 (3), pp. 274-9. |
| DOI: |
10.1159/000125233 |
| Abstrakt: |
Pineal beta-adrenoceptor density and affinity in ewes are modified in a season-dependent manner by gonadal steroids and by the sympathetic innervation of the gland. The present study was undertaken to relate the steroidal effects on the receptors to post receptor endocrine events, and to investigate the influence of the sympathetic innervation of the pineal gland on these events. Plasma melatonin and prolactin profiles were determined during anestrus and during the normal breeding season in ewes subjected to sympathetic denervation of the pineal and/or a range of steroid-related treatments. Wherever valid comparisons could be drawn between effects of the treatments on beta-adrenoceptor variables and on circulating hormone levels, similar effects were noted. Further, ganglionectomy influenced hormone profiles similarly to estradiol under all conditions tested. It appears that gonadal steroids (estradiol) and the sympathetic neurotransmitter noradrenaline have opposing actions on prolactin levels, just as they have on pineal beta-adrenoceptor binding affinity. These findings suggest that steroid-mediated changes in receptor number and affinity are reflected in post receptor endocrine events. In addition, other factors (e.g. photoperiodic information transmitted via the sympathetic innervation) also play important roles in the regulation of the observed hormonal profiles. A steroid-mediated feedback regulation of pituitary prolactin release, partly direct and partly via pineal melatonin release, is suggested. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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