Daily iTBS worsens hand motor training--a combined TMS, fMRI and mirror training study.

Autor: Läppchen CH; Department of Neurology, University Medical Centre, Freiburg, Germany. Electronic address: claus.henning.laeppchen@uniklinik-freiburg.de., Ringer T; Section of Neurological Rehabilitation, Hans Berger Department of Neurology, Jena University Hospital, Germany., Blessin J; Section of Neurological Rehabilitation, Hans Berger Department of Neurology, Jena University Hospital, Germany., Schulz K; Section of Neurological Rehabilitation, Hans Berger Department of Neurology, Jena University Hospital, Germany; Department of Neurology, Moritz Klinik Bad Klosterlausnitz, Germany; Center for Sepsis Control and Care, Jena University Hospital, Germany., Seidel G; Section of Neurological Rehabilitation, Hans Berger Department of Neurology, Jena University Hospital, Germany; Department of Neurology, Moritz Klinik Bad Klosterlausnitz, Germany., Lange R; Department of Neurology, Nuremberg Municipal Hospital, Germany., Hamzei F; Section of Neurological Rehabilitation, Hans Berger Department of Neurology, Jena University Hospital, Germany; Department of Neurology, Moritz Klinik Bad Klosterlausnitz, Germany; Center for Sepsis Control and Care, Jena University Hospital, Germany.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2015 Feb 15; Vol. 107, pp. 257-265. Date of Electronic Publication: 2014 Dec 13.
DOI: 10.1016/j.neuroimage.2014.12.022
Abstrakt: Introduction: Repetitive transcranial magnetic stimulation (rTMS) is used to increase regional excitability to improve motor function in combination with training after neurological diseases or events such as stroke. We investigated whether a daily application of intermittent theta burst stimulation (iTBS; a short-duration rTMS that increases regional excitability) improves the training effect compared with sham stimulation in association with a four-day hand training program using a mirror (mirror training, MT). The right dorsal premotor cortex (dPMC right) was chosen as the target region for iTBS because this region has recently been emphasized as a node within a network related to MT.
Methods: Healthy subjects were randomized into the iTBS group or sham group (control group CG). In the iTBS group, iTBS was applied daily over dPMC right, which was functionally determined in an initial fMRI session prior to starting MT. MT involved 20 min of hand training daily in a mirror over four days. The hand tests, the intracortical excitability and fMRI were evaluated prior to and at the end of MT.
Results: The results of the hand training tests of the iTBS group were surprisingly significantly poorer compared with those from the CG group. Both groups showed a different course of excitability in both M1 and a different course of fMRI activation within the supplementary motor area and M1 left.
Conclusion: We suggest the inter-regional functional balance was affected by daily iTBS over dPMC right. Maybe an inter-regional connectivity within a network is differentially balanced. An excitability increase within an inhibitory-balanced network would therefore disturb the underlying network.
(Copyright © 2014 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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