Multiple human papillomavirus infections are highly prevalent in the anal canal of human immunodeficiency virus-positive men who have sex with men.
| Autor: | Méndez-Martínez R; División de Investigación, Instituto Nacional de Cancerología, Secretaría de Salud (SSA), México D.F., Mexico. rocmenmar@yahoo.com., Rivera-Martínez NE; Instituto Nacional de Ciencias Médicas y Nutrición 'Salvador Zubirán,' SSA, México D.F., Mexico. normaerm@hotmail.com., Crabtree-Ramírez B; Instituto Nacional de Ciencias Médicas y Nutrición 'Salvador Zubirán,' SSA, México D.F., Mexico. brendcrabtree@hotmail.com., Sierra-Madero JG; Instituto Nacional de Ciencias Médicas y Nutrición 'Salvador Zubirán,' SSA, México D.F., Mexico. jsmadero@yahoo.com., Caro-Vega Y; Instituto Nacional de Ciencias Médicas y Nutrición 'Salvador Zubirán,' SSA, México D.F., Mexico. yaninkc@yahoo.com.mx., Galván SC; Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México D.F., Mexico. sgalvan@servidor.unam.mx., de León DC; Dirección de Investigación Clínica, Instituto Nacional de Cancerología, Secretaría de Salud (SSA), México D.F., Mexico. dcantu3@excite.com., García-Carrancá A; Unidad de Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México and Instituto Nacional de Cancerología, SSA, México D.F., Mexico. carranca@biomedicas.unam.mx.; Laboratory of Virus & Cancer Instituto Nacional de Cancerología, Av. San Fernando No. 22, Colonia Sección XVI, México D.F., Tlalpan, 14080, México. carranca@biomedicas.unam.mx. |
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| Jazyk: | angličtina |
| Zdroj: | BMC infectious diseases [BMC Infect Dis] 2014 Dec 16; Vol. 14, pp. 671. Date of Electronic Publication: 2014 Dec 16. |
| DOI: | 10.1186/s12879-014-0671-4 |
| Abstrakt: | Background: Anal cancer has become one of the most common non-AIDS-defined tumors among Human Immunodeficiency Virus-positive (HIV+) individuals, and a rise in its incidence among HIV+ Men who have Sex with Men (MSM) has been shown, despite the introduction of Highly Active Anti-Retroviral Therapy (HAART). Human Papillomavirus (HPV) infections are highly prevalent among HIV+ MSM and recent studies have shown high rates of HPV-associated anal intraepithelial neoplasia (AIN) and anal cancer among this population. Methods: In the present study we determined the prevalence and nature of HPV co-infections in the anal canal of 324 HIV+ MSM attending a high specialty medical center in Mexico City, DNA extraction and amplification with generic primers for HPV was performed, followed by detection of specific types and co-infections with INNO-Lipa, and identification of variants by amplification and sequencing of the E6 and LCR region of HPV 16. Results: We found a very high prevalence of HPV infections among this cohort (86%), with more than one fourth of them (28%) positive for type 16. Among HPV16-positive patients, European variants were the most prevalent, followed by Asian-American ones. Among these individuals (HPV-16+), we identified co-infections with other 21 HPV types namely; 11, 51, 52, 6, 66, 68, 74, 18, 45, 35, 26, 44, 70, 53, 54, 82, 31, 33, 56, 58, 59. Conclusions: HIV+ MSM show a very high rate of HPV infections in the anal canal and those with type 16 exhibited a multiplicity of associated types. This study emphasizes the need for an early detection of HPV infections among HIV+ MSM in order to establish its utility to prevent anal neoplasia and cancer. |
| Databáze: | MEDLINE |
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