Coapplication of lidocaine and membrane-impermeable lidocaine derivative QX-222 produces divergent effects on evoked and spontaneous nociceptive behaviors in mice.

Autor: Hu SP; Department of Anesthesiology, Huzhou Central Hospital, Huzhou 313000, China., Zhao JJ; Department of Orthopedics, Huzhou Central Hospital, Hongqi Road No. 198, Huzhou 313000, China., Wang WX; Department of Anesthesiology, Huzhou Central Hospital, Huzhou 313000, China., Liu Y; Department of Anesthesiology, Huzhou Central Hospital, Huzhou 313000, China., Wu HF; Department of Anesthesiology, Huzhou Central Hospital, Huzhou 313000, China., Chen C; Department of Anesthesiology, Huzhou Central Hospital, Huzhou 313000, China., Yu L; Department of Anesthesiology, Huzhou Central Hospital, Huzhou 313000, China., Gui JB; Department of Anesthesiology, Huzhou Central Hospital, Huzhou 313000, China.
Jazyk: angličtina
Zdroj: BioMed research international [Biomed Res Int] 2014; Vol. 2014, pp. 628729. Date of Electronic Publication: 2014 Nov 24.
DOI: 10.1155/2014/628729
Abstrakt: The present study was aimed at investigating the analgesic properties of a combination of lidocaine and QX-222 and its effects on evoked pain behavior (complete Freund's adjuvant-induced allodynia and hyperalgesia in inflammatory condition) and spontaneous pain behavior (formalin-induced acute pain) in mice. Drugs were injected adjacent to sciatic nerve or into plantar. Motor function, thermal withdrawal latency, mechanical withdrawal threshold, and licking/biting were evaluated by behavioral tests. A combination of lidocaine and QX-222 adjacent sciatic nerve injection produced the long-lasting sensory-specific nerve block, and intraplantar injection inhibited spontaneous pain in the formalin-treated mice but did not detectably attenuated hyperalgesia and allodynia in the complete Freund's adjuvant- (CFA-) treated mice. Our results suggest that a combination of lidocaine and QX-222 achieves a long-lasting differential block (sensory selective) and produces divergent effects on evoked and spontaneous pain behaviors in mice.
Databáze: MEDLINE
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