Successfully treated calcific uremic arteriolopathy: two cases of a high anion gap metabolic acidosis with intravenous sodium thiosulfate.
| Autor: | Rein JL; Department of Medicine, Mount Sinai Beth Israel, 350 E 17th Street, 20th Floor Baird Hall, New York, NY 10003, USA., Miyata KN; Department of Medicine, Mount Sinai Beth Israel, 350 E 17th Street, 20th Floor Baird Hall, New York, NY 10003, USA., Dadzie KA; Division of Nephrology and Hypertension, Mount Sinai Beth Israel, 350 E 17th Street, 18th Floor Baird Hall, New York, NY 10003, USA., Gruber SJ; Division of Nephrology and Hypertension, Mount Sinai Beth Israel, 350 E 17th Street, 18th Floor Baird Hall, New York, NY 10003, USA., Sulica R; Department of Pulmonary, Critical Care & Sleep Medicine, Mount Sinai Beth Israel, 7 Dazian Building, 1st Avenue at 16th Street, New York, NY 10003, USA., Winchester JF; Division of Nephrology and Hypertension, Mount Sinai Beth Israel, 350 E 17th Street, 18th Floor Baird Hall, New York, NY 10003, USA. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Case reports in nephrology [Case Rep Nephrol] 2014; Vol. 2014, pp. 765134. Date of Electronic Publication: 2014 Nov 19. |
| DOI: | 10.1155/2014/765134 |
| Abstrakt: | Calcific uremic arteriolopathy (CUA) is a rare and potentially fatal disorder of calcification involving subcutaneous small vessels and fat in patients with renal insufficiency. We describe the successful use of intravenous sodium thiosulfate (STS) for the treatment of CUA in two patients. The first case was complicated by the development of a severe anion gap metabolic acidosis, which was accompanied by a seizure. Both patients had complete wound healing within five months. Although STS should be considered in the treatment of CUA, little is known about pharmacokinetics and additional studies are required to determine dosing strategies to minimize severe potential side effects. |
| Databáze: | MEDLINE |
| Externí odkaz: |
|