An outbreak of type π vaccine-derived poliovirus in Sichuan province, China: emergence and circulation in an under-immunized population.

Autor: Wang HB; Chinese Center for Disease Control and Prevention, Nanwei Rd 27#, Xicheng District, Beijing 100050, PR China; Peking University Clinical Research Institute, Xueyuan Rd 38#, Haidian District, Beijing 100191, PR China., Fang G; Sichuan Provincial Center for Disease Control and Prevention, Zhongxue Road 6#, Chengdu City, Sichuan Province 610041, PR China., Yu WZ; Chinese Center for Disease Control and Prevention, Nanwei Rd 27#, Xicheng District, Beijing 100050, PR China., Du F; Sichuan Provincial Center for Disease Control and Prevention, Zhongxue Road 6#, Chengdu City, Sichuan Province 610041, PR China., Fan CX; Chinese Center for Disease Control and Prevention, Nanwei Rd 27#, Xicheng District, Beijing 100050, PR China., Liu QL; Sichuan Provincial Center for Disease Control and Prevention, Zhongxue Road 6#, Chengdu City, Sichuan Province 610041, PR China., Hao LX; Chinese Center for Disease Control and Prevention, Nanwei Rd 27#, Xicheng District, Beijing 100050, PR China., Liu Y; Sichuan Provincial Center for Disease Control and Prevention, Zhongxue Road 6#, Chengdu City, Sichuan Province 610041, PR China., Zheng JS; Chinese Center for Disease Control and Prevention, Nanwei Rd 27#, Xicheng District, Beijing 100050, PR China., Qin ZY; Sichuan Provincial Center for Disease Control and Prevention, Zhongxue Road 6#, Chengdu City, Sichuan Province 610041, PR China., Xia W; Chinese Center for Disease Control and Prevention, Nanwei Rd 27#, Xicheng District, Beijing 100050, PR China., Zhang SY; Ngawa Tibetan and Qiang Autonomous Prefectural Center for Disease Control and Prevention, Meigu Street 178#, Maerkang County, Ngawa Tibetan and Qiang Autonomous Prefecture, Sichuan Province 624000, PR China., Yin ZD; Chinese Center for Disease Control and Prevention, Nanwei Rd 27#, Xicheng District, Beijing 100050, PR China., Jing Q; Ngawa Tibetan and Qiang Autonomous Prefectural Center for Disease Control and Prevention, Meigu Street 178#, Maerkang County, Ngawa Tibetan and Qiang Autonomous Prefecture, Sichuan Province 624000, PR China., Zhang YX; Chinese Center for Disease Control and Prevention, Nanwei Rd 27#, Xicheng District, Beijing 100050, PR China., Huang RN; Chengdu City Center for Disease Control and Prevention, Longxiang Rd 4#, Chengdu City, Sichuan Province 610041, PR China., Yang RP; Chengdu City Center for Disease Control and Prevention, Longxiang Rd 4#, Chengdu City, Sichuan Province 610041, PR China., Tong WB; Sichuan Provincial Center for Disease Control and Prevention, Zhongxue Road 6#, Chengdu City, Sichuan Province 610041, PR China., Qi Q; Sichuan Provincial Center for Disease Control and Prevention, Zhongxue Road 6#, Chengdu City, Sichuan Province 610041, PR China., Guan XJ; Sichuan Provincial Center for Disease Control and Prevention, Zhongxue Road 6#, Chengdu City, Sichuan Province 610041, PR China., Jing YL; Sichuan Provincial Center for Disease Control and Prevention, Zhongxue Road 6#, Chengdu City, Sichuan Province 610041, PR China., Ma QL; Sichuan Provincial Center for Disease Control and Prevention, Zhongxue Road 6#, Chengdu City, Sichuan Province 610041, PR China., Wang J; Sichuan Provincial Center for Disease Control and Prevention, Zhongxue Road 6#, Chengdu City, Sichuan Province 610041, PR China., Ma XZ; Sichuan Provincial Center for Disease Control and Prevention, Zhongxue Road 6#, Chengdu City, Sichuan Province 610041, PR China., Chen N; Sichuan Provincial Center for Disease Control and Prevention, Zhongxue Road 6#, Chengdu City, Sichuan Province 610041, PR China., Zheng HR; Sichuan Provincial Center for Disease Control and Prevention, Zhongxue Road 6#, Chengdu City, Sichuan Province 610041, PR China., Li YQ; Sichuan Provincial Center for Disease Control and Prevention, Zhongxue Road 6#, Chengdu City, Sichuan Province 610041, PR China., Ma C; Chinese Center for Disease Control and Prevention, Nanwei Rd 27#, Xicheng District, Beijing 100050, PR China., Su QR; Chinese Center for Disease Control and Prevention, Nanwei Rd 27#, Xicheng District, Beijing 100050, PR China., Reilly KH; National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Nanwei Rd 27#, Xicheng District, Beijing 100050, PR China., Luo HM; Chinese Center for Disease Control and Prevention, Nanwei Rd 27#, Xicheng District, Beijing 100050, PR China., Wu XP; Sichuan Provincial Center for Disease Control and Prevention, Zhongxue Road 6#, Chengdu City, Sichuan Province 610041, PR China., Wen N; Chinese Center for Disease Control and Prevention, Nanwei Rd 27#, Xicheng District, Beijing 100050, PR China., Yang WZ; Chinese Center for Disease Control and Prevention, Nanwei Rd 27#, Xicheng District, Beijing 100050, PR China.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2014 Dec 11; Vol. 9 (12), pp. e113880. Date of Electronic Publication: 2014 Dec 11 (Print Publication: 2014).
DOI: 10.1371/journal.pone.0113880
Abstrakt: Background: During August 2011-February 2012, an outbreak of type Π circulating vaccine-derived poliovirus (cVDPVs) occurred in Sichuan Province, China.
Methods: A field investigation of the outbreak was conducted to characterize outbreak isolates and to guide emergency response. Sequence analysis of poliovirus capsid protein VP1 was performed to determine the viral propagation, and a coverage survey was carried out for risk assessment.
Results: One clinical compatible polio case and three VDPV cases were determined in Ngawa County, Ngawa Tibetan and Qiang Autonomous Prefecture, Sichuan Province. Case patients were unimmunized children, 0.8-1 years old. Genetic sequencing showed that the isolates diverged from the VP1 region of the type Π Sabin strain by 5-12 nucleotides (nt) and shared the same 5 nt VP1 substitutions, which indicate single lineage of cVDPVs. Of the 7 acute flaccid paralysis cases (all>6 months) reported in Ngawa Prefecture in 2011, 4 (57.1%) cases (including 2 polio cases) did not receive oral attenuated poliovirus vaccine. Supplementary immunization activities (SIAs) were conducted in February-May, 2012, and the strain has not been isolated since.
Conclusion: High coverage of routine immunization should be maintained among children until WPV transmission is globally eradicated. Risk assessments should be conducted regularly to pinpoint high risk areas or subpopulations, with SIAs developed if necessary.
Databáze: MEDLINE
Externí odkaz: