Topical Cyclosporine A 1% for the Treatment of Chronic Follicular Conjunctivitis.

Autor:	Kolomeyer AM; Department of Pittsburgh (A.M.K.), University of Pittsburgh Medical Center, Pittsburgh, PA; Institute of Ophthalmology and Visual Science (N.V.N., A.R., J.S.K., C.F., E.S.K., D.S.C.), Rutgers University, Newark, NJ; and Metropolitan Eye Research and Surgery Institute (D.S.C.), Palisades Park, NJ., Nayak NV, Ragam A, Kim JS, Fang C, Kim ES, Chu DS
Jazyk:	angličtina
Zdroj:	Eye & contact lens [Eye Contact Lens] 2015 Jul; Vol. 41 (4), pp. 210-3.
DOI:	10.1097/ICL.0000000000000099
Abstrakt:	Objective: To evaluate the use of topical cyclosporine A (CSA) 1% in the treatment of chronic follicular conjunctivitis (CFC). Methods: Retrospective chart review from 2001 to 2012 identified 12 patients (22 eyes) with CFC (mean ± standard deviation [SD] age, 50.2 ± 15.4 years; 75% female; 92% white) treated with CSA. Main outcome measures included inflammation grade, visual acuity, concurrent corticosteroid (CS) therapy, effect on CS taper, and adverse effects. Results: Mean ± SD follow-up time was 11.7 ± 9.7 months. Mean ± SD time from diagnosis to CSA treatment initiation was 2.4 ± 3.2 months. Mean ± SD duration of CSA treatment was 5.8 ± 2.8 months. Four patients (33%) complained of irritation (n = 2), redness (n = 1), itching (n = 1), and burning (n = 1) but none discontinued treatment. Concurrent CSs were tapered off in all patients after a mean ± SD of 5.0 ± 2.5 weeks. Mean ± SD initial vision was 0.078 ± 0.093 logMAR, whereas vision at final examination was 0.056 ± 0.081 logMAR (P = 0.02). Mean ± SD initial inflammation grade of 1.9 ± 1.0 was significantly reduced to final grade of 0.7 ± 0.9 (P = 0.0002). Mean ± SD time to initial inflammation control in 9 patients (75%) was 33.2 ± 24.5 days. Two patients (17%) switched to oral CSA because of lack of inflammation control. Conclusions: Topical CSA 1% is an effective and well-tolerated therapy that decreased chronic inflammation and tapered topical CS in patients with CFC. The use of CSA in such patients warrants further investigation.
Databáze:	MEDLINE
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