The past, present and future in scaffold-based tendon treatments.

Autor: Lomas AJ; Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland., Ryan CN; Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland., Sorushanova A; Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland., Shologu N; Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland., Sideri AI; Veterinary Faculty, University of Thessaly, Karditsa, Greece., Tsioli V; Veterinary Faculty, University of Thessaly, Karditsa, Greece., Fthenakis GC; Veterinary Faculty, University of Thessaly, Karditsa, Greece., Tzora A; Animal Production Division, Department of Agriculture Technology, TEI of Epirus, Arta, Greece., Skoufos I; Animal Production Division, Department of Agriculture Technology, TEI of Epirus, Arta, Greece., Quinlan LR; Department of Physiology, NUI Galway, Ireland., O'Laighin G; College of Engineering and Informatics, NUI Galway, Galway, Ireland., Mullen AM; Teagasc Research Centre, Ashtown, Ireland., Kelly JL; Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland; Department of Surgery, NUI Galway, Galway, Ireland., Kearns S; Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland; University College Hospitals Galway (UCHG), Galway, Ireland., Biggs M; Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland., Pandit A; Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland., Zeugolis DI; Network of Excellence for Functional Biomaterials (NFB), Biosciences Research Building, National University of Ireland Galway (NUI Galway), Galway, Ireland. Electronic address: dimitrios.zeugolis@nuigalway.ie.
Jazyk: angličtina
Zdroj: Advanced drug delivery reviews [Adv Drug Deliv Rev] 2015 Apr; Vol. 84, pp. 257-77. Date of Electronic Publication: 2014 Dec 10.
DOI: 10.1016/j.addr.2014.11.022
Abstrakt: Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent, especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics/biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come.
(Copyright © 2014 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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