Electrochemotherapy - possible benefits and limitations to its use in the head and neck region.

Autor: Landström FJ; Departments of Otolaryngology., Reizenstein JA, Nilsson CO, Beckerath MV, Löfgren AL, Adamsson GB, Möller C
Jazyk: angličtina
Zdroj: Acta oto-laryngologica [Acta Otolaryngol] 2015 Jan; Vol. 135 (1), pp. 90-5.
DOI: 10.3109/00016489.2014.947655
Abstrakt: Conclusion: Electrochemotherapy (ECT) is an efficacious treatment. It should, however, be used with some caution in the treatment of head and neck cancer.
Objectives: To assess local tumor control, safety, survival, and functional outcome after treatment of cancer in the head and neck region with ECT.
Methods: Four patients with primary T2 cancer of the oral cavity or oropharynx and one patient with a metastasis of renal cancer in the masseter muscle were treated with ECT with intratumorally administered bleomycin. Control biopsies were carried out 2 months after treatment. Postoperative radiotherapy was performed based on tumor T-stage and the depth of tumor infiltration. Serious adverse events and treatment malfunctions were recorded. The follow-up time was 24 months for the surviving patients and 20 months overall. The PSS-HN scale was used to assess the functional outcome.
Results: No local recurrence was recorded in any patient during the follow-up. However, only one patient was treated with ECT alone. There were four serious adverse events: one nearly lethal bleeding, two cases of osteoradionecrosis, and a fistula. One patient died from distant metastasis. The other patients were tumor-free both locally and overall at 24 months. The median functional outcome in all parameters was worse 1 year after treatment.
Databáze: MEDLINE
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