Jorge Lobo's disease: immunohistochemical characterization of dendritic cells in cutaneous lesions.

Autor: Barboza TC; Instituto de Assistência Médica ao Servidor Público Estadual, Programa de pós-graduação em Ciências da Saúde, São Paulo, SP, Brazil., Quaresma JA, de Brito AC, Xavier MB, de Oliveira CM, Unger DA, Duarte MI, Sotto MN, Pagliari C
Jazyk: angličtina
Zdroj: Mycopathologia [Mycopathologia] 2015 Apr; Vol. 179 (3-4), pp. 269-74. Date of Electronic Publication: 2014 Dec 07.
DOI: 10.1007/s11046-014-9836-3
Abstrakt: Background: Jorge Lobo's disease (JLD) is a cutaneous chronic mycosis caused by Lacazia loboi. We studied Factor XIIIa + dermal dendrocytes (FXIIIa + DD), Langerhans cells (LC) through the expression of langerin and the expression of S100 protein.
Methods: A total of 41 biopsies and 10 normal skins (control) were developed with a polymer-based immunohistochemical method.
Results: Lesions presented infiltrate comprising macrophages, some asteroid corpuscles, lymphocytes, multinucleated giant cells and a large number of fungi. LCs presented short dendrites and were scarcely distributed. Dermal langerin + cells were detected in nine JLD lesions. FXIIIa + DD were hypertrophic, visualized in the inflammatory infiltrate of JLD lesions. Cells S100+ were present in JLD and control group with a similar number of cells. A total of 14 specimens did not express FXIIIa, and this considerable number probably contributed to the statistical similarity with the control group.
Conclusions: The results indicate that LCs are present in the immune response against Lacazia loboi. Some dermal langerin + cells could be another subset of dendritic cells. Our data indicate changes of LCs in JLD cutaneous lesions and present, for the first time, results that show langerin + cells in the dermis and corroborate previous observations on the participation of FXIIIa + DD in the in situ immune response in JLD.
Databáze: MEDLINE
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