| Autor: |
Elzahhar PA, Soliman R, El-Hawash SA, Ragab HM, Youssef AM, Wahab AE; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt. soadhawash@yahoo.com. |
| Jazyk: |
angličtina |
| Zdroj: |
Medicinal chemistry (Shariqah (United Arab Emirates)) [Med Chem] 2015; Vol. 11 (4), pp. 407-14. |
| DOI: |
10.2174/1573406411666141205102544 |
| Abstrakt: |
This work describes the synthesis of new series of compounds derived from methyl pyridyl- 2,4-dioxobutanoates that contain pyridine ring attached to substituted bioactive heterocyclic moieties in order to investigate their preliminary in vitro antibacterial and antifungal activities. The results revealed that most of the tested compounds exhibited significant activity against P. aeruginosa. and E. coli. They also displayed considerable activity against S. aureus and B. subtilis. On the other hand, the compounds displayed moderate antifungal activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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