Evaluation of usefulness of serum insulin as sensitive predictor of cardiovascular dysfunction in obese individuals with normal lipid profile.

Autor: Bakshi AA; Assistant Professor, Department of Biochemistry, Terna Medical College , Nerul, Navi Mumbai, Maharashtra, India ., Bavikar JS; Associate Professor, Department of Biochemistry, Government Medical College , Aurangabad, Maharashtra, India ., Asegaonkar SB; Assistant Professor, Department of Biochemistry, Government Medical College , Aurangabad, Maharashtra, India ., Bardapurkar JS; Ex Professor and Head, Department of Biochemistry, Govt Medical College , Aurangabad, India ., Domple V; Assistant Professor, Department of Community Medicine, Government Medical College , Nanded, Maharashtra, India ., Rai PS; Associate Professor, Department of Biochemistry, Lokmanya Tilak med College , Mumbai, Maharashtra, India ., Pawar S; Assistant Professor, Department of Biochemistry, Lokmanya Tilak med College , Mumbai, Maharashtra, India .
Jazyk: angličtina
Zdroj: Journal of clinical and diagnostic research : JCDR [J Clin Diagn Res] 2014 Oct; Vol. 8 (10), pp. CC10-2. Date of Electronic Publication: 2014 Oct 20.
DOI: 10.7860/JCDR/2014/9759.4980
Abstrakt: Background: Prevalence of obesity and its subsequent cardiometabolic complications is on exponential rise. Hyperinsulinemia develops in obese individuals long before other metabolic derangements of obesity take place and may be a common pathophysiological factor tying together various components of cardiometabolic dysfunction.
Aim: Present study was aimed at evaluating the role of insulin as a sensitive and independent cardiovascular risk marker in apparently healthy overweight and obese individuals with normal lipid profile.
Settings and Design: This was an opd based case Control study including 100 overweight and obese individuals with normal lipid profile & 100 age and sex matched normal weight healthy controls.
Materials and Methods: Participants were evaluated based on detailed history, clinical examination and laboratory investigations. Blood samples were collected after overnight fast. Serum insulin was estimated by chemiluminescence method, glucose and lipid profile (CHOLESTEROL, HDL, TG, LDL) by chemical assays on a fully automated analyser system.
Statistical Analysis: RESULTS were analyzed by unpaired t-test, p-value was determined & Correlation coefficient was calculated amongst various parameters.
Results: Significant difference was noted in mean values of BMI (29.69±1.28 VS 23.47±1.09), waist / hip ratio (0.91±0.07 VS 0.79±0.05) and serum insulin (10.54±2.5 VS 5.94±1.53) (p<0.01) in cases as compared to controls respectively. Glucose levels were high in cases (89.58±8.0 mg/dl) as compared to controls (88.8±7.56 mg/dl) but the difference was statistically insignificant (p=0.11). Hyperinsulinemia was observed in 41 cases & 4 controls. Serum insulin highly correlated with Waist/ hip ratio (R=0.53) than BMI (R=0.26).
Conclusion: Study suggests Insulin; a simple, sensitive & independent cardiovascular risk predictor in obesity even with normal lipid profile with a potential to reveal hidden burden of metabolic dysfunction and offers a hope that, cardiovascular event can be well prevented with appropriate interventions.
Databáze: MEDLINE
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