Imaging genomics of Glioblastoma: state of the art bridge between genomics and neuroradiology.
| Autor: | ElBanan MG; Department of Diagnostic Radiology, MD Anderson Cancer Center, University of Texas, 1400 Pressler Street, Houston, TX 77030, USA., Amer AM; Department of Diagnostic Radiology, MD Anderson Cancer Center, University of Texas, 1400 Pressler Street, Houston, TX 77030, USA., Zinn PO; Department of Neurosurgery, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA., Colen RR; Department of Diagnostic Radiology, MD Anderson Cancer Center, University of Texas, 1400 Pressler Street, Houston, TX 77030, USA. Electronic address: rcolen@mdanderson.org. |
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| Jazyk: | angličtina |
| Zdroj: | Neuroimaging clinics of North America [Neuroimaging Clin N Am] 2015 Feb; Vol. 25 (1), pp. 141-53. |
| DOI: | 10.1016/j.nic.2014.09.010 |
| Abstrakt: | Glioblastoma (GBM) is the most common and most aggressive primary malignant tumor of the central nervous system. Recently, researchers concluded that the "one-size-fits-all" approach for treatment of GBM is no longer valid and research should be directed toward more personalized and patient-tailored treatment protocols. Identification of the molecular and genomic pathways underlying GBM is essential for achieving this personalized and targeted therapeutic approach. Imaging genomics represents a new era as a noninvasive surrogate for genomic and molecular profile identification. This article discusses the basics of imaging genomics of GBM, its role in treatment decision-making, and its future potential in noninvasive genomic identification. (Copyright © 2015 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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