Long non-coding RNAs and hepatocellular carcinoma.
| Autor: | Yu FJ; Department of Gastroenterology, Jinshan Hospital of Fudan University, Jinshan, Shanghai 201508., Zheng JJ; Wenzhou Key Laboratory of Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China., Dong PH; Wenzhou Key Laboratory of Surgery, Department of Infectious Diseases, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China., Fan XM; Department of Gastroenterology, Jinshan Hospital of Fudan University, Jinshan, Shanghai 201508. |
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| Jazyk: | angličtina |
| Zdroj: | Molecular and clinical oncology [Mol Clin Oncol] 2015 Jan; Vol. 3 (1), pp. 13-17. Date of Electronic Publication: 2014 Sep 25. |
| DOI: | 10.3892/mco.2014.429 |
| Abstrakt: | Recent advances in next-generation sequencing technology in transcriptome analysis have helped identify numerous non-coding RNAs. The long non-coding RNA (lncRNA) is commonly defined as an RNA molecule with a length of 200 bp-100 kbp that lacks protein-coding potential. LncRNAs play a critical role in the regulation of gene expression, including chromatin modification, transcription and post-transcriptional processing. It has been confirmed that dysregulation of lncRNAs is associated with a number of human diseases, particularly tumors. In this study, we focused on the most extensively investigated lncRNAs in hepatocellular carcinoma (HCC). The biological functions and molecular mechanisms of the majority of lncRNAs have yet to be investigated. The improved knowledge on lncRNAs in HCC may help identify lncRNAs that may be used as novel prognostic markers and therapeutic targets. |
| Databáze: | MEDLINE |
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