The uptake of soluble and nanoparticulate imaging isotope in model liver tumours after intra-venous and intra-arterial administration.

Autor: Stephens RW; Biomedical Radiochemistry Laboratory, Department of Applied Mathematics, Research School of Physics and Engineering, Australian National University, Australia. Electronic address: ross.stephens@anu.edu.au., Knox KJ; Biomedical Radiochemistry Laboratory, Department of Applied Mathematics, Research School of Physics and Engineering, Australian National University, Australia., Philip LA; Animal Services Division, Research School of Biology, Australian National University, Australia., Debono KM; Animal Services Division, Research School of Biology, Australian National University, Australia., Bell JL; Biomedical Radiochemistry Laboratory, Department of Applied Mathematics, Research School of Physics and Engineering, Australian National University, Australia., King DW; Biomedical Radiochemistry Laboratory, Department of Applied Mathematics, Research School of Physics and Engineering, Australian National University, Australia., Parish CR; Vascular Biology Laboratory, John Curtin School of Medical Research, Australian National University, Australia., Senden TJ; Biomedical Radiochemistry Laboratory, Department of Applied Mathematics, Research School of Physics and Engineering, Australian National University, Australia., Tanudji MR; Sirtex Medical Ltd, Sydney, Australia., Winter JG; Sirtex Medical Ltd, Sydney, Australia., Bickley SA; Sirtex Medical Ltd, Sydney, Australia., Tapner MJ; Sirtex Medical Ltd, Sydney, Australia., Pang JH; Sirtex Medical Ltd, Sydney, Australia., Jones SK; Sirtex Medical Ltd, Sydney, Australia.
Jazyk: angličtina
Zdroj: Biomaterials [Biomaterials] 2015 Jan; Vol. 39, pp. 218-24. Date of Electronic Publication: 2014 Nov 20.
DOI: 10.1016/j.biomaterials.2014.11.001
Abstrakt: Delivery of chemotherapeutic drugs to tumours by reformulation as nanoparticles has often been proposed as a means of facilitating increased selective uptake, exploiting the increased permeability of the tumour vasculature. However realisation of this improvement in drug delivery in cancer patients has met with limited success. We have compared tumour uptake of soluble Tc99m-pertechnetate and a colloid of nanoparticles with a Tc99m core, using both intra-venous and intra-arterial routes of administration in a rabbit liver VX2 tumour model. The radiolabelled nanoparticles were tested both in untreated and cationised form. The results from this tumour model in an internal organ show a marked advantage in intra-arterial administration over the intra-venous route, even for the soluble isotope. Tumour accumulation of nanoparticles from arterial administration was augmented by cationisation of the nanoparticle surface with histone proteins, which consistently facilitated selective accumulation within microvessels at the periphery of tumours.
(Copyright © 2014 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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